Hu DX - Search Results

1

Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents.

Zhang XR, Wang HW, Tang WL, Zhang Y, Yang H, Hu DX, Ravji A, Marchand C, Kiselev E, Ofori-Atta K, Agama K, Pommier Y, An LK. Zhang XR, et al. Among authors: hu dx. J Med Chem. 2018 Nov 21;61(22):9908-9930. doi: 10.1021/acs.jmedchem.8b00639. Epub 2018 Oct 31. J Med Chem. 2018. PMID: 30336023 Free PMC article.

2

Syntheses and evaluation of new Quinoline derivatives for inhibition of hnRNP K in regulating oncogene c-myc transcription.

Shu B, Zeng P, Kang S, Li PH, Hu D, Kuang G, Cao J, Li X, Zhang M, An LK, Huang ZS, Li D. Shu B, et al. Bioorg Chem. 2019 Apr;85:1-17. doi: 10.1016/j.bioorg.2018.12.020. Epub 2018 Dec 22. Bioorg Chem. 2019. PMID: 30599408

3

Synthesis and biological evaluation of 5-aminoethyl benzophenanthridone derivatives as DNA topoisomerase IB inhibitors.

Tang WL, Zhang Y, Hu DX, Yang H, Yu Q, Chen JW, Agama K, Pommier Y, An LK. Tang WL, et al. Among authors: hu dx. Eur J Med Chem. 2019 Sep 15;178:81-92. doi: 10.1016/j.ejmech.2019.05.074. Epub 2019 May 30. Eur J Med Chem. 2019. PMID: 31176097 Free PMC article.

4

Synthesis and biological evaluation of novel indole-pyrazoline hybrid derivatives as potential topoisomerase 1 inhibitors.

Shu B, Yu Q, Hu DX, Che T, Zhang SS, Li D. Shu B, et al. Among authors: hu dx. Bioorg Med Chem Lett. 2020 Feb 15;30(4):126925. doi: 10.1016/j.bmcl.2019.126925. Epub 2019 Dec 26. Bioorg Med Chem Lett. 2020. PMID: 31901379

5

Secondary metabolites from Isodon ternifolius (D. Don) Kudo and their anticancer activity as DNA topoisomerase IB and Tyrosyl-DNA phosphodiesterase 1 inhibitors.

Zhang HL, Zhang Y, Yan XL, Xiao LG, Hu DX, Yu Q, An LK. Zhang HL, et al. Among authors: hu dx. Bioorg Med Chem. 2020 Jun 1;28(11):115527. doi: 10.1016/j.bmc.2020.115527. Epub 2020 Apr 22. Bioorg Med Chem. 2020. PMID: 32345458

6

Syntheses and Evaluation of New Bisacridine Derivatives for Dual Binding of G-Quadruplex and i-Motif in Regulating Oncogene c-myc Expression.

Kuang G, Zhang M, Kang S, Hu D, Li X, Wei Z, Gong X, An LK, Huang ZS, Shu B, Li D. Kuang G, et al. J Med Chem. 2020 Sep 10;63(17):9136-9153. doi: 10.1021/acs.jmedchem.9b01917. Epub 2020 Aug 26. J Med Chem. 2020. PMID: 32787078

7

The synthesis of furoquinolinedione and isoxazoloquinolinedione derivatives as selective Tyrosyl-DNA phosphodiesterase 2 (TDP2) inhibitors.

Yang H, Zhu XQ, Wang W, Chen Y, Hu Z, Zhang Y, Hu DX, Yu LM, Agama K, Pommier Y, An LK. Yang H, et al. Among authors: hu z, hu dx. Bioorg Chem. 2021 Jun;111:104881. doi: 10.1016/j.bioorg.2021.104881. Epub 2021 Apr 1. Bioorg Chem. 2021. PMID: 33839584 Free PMC article.

8

Synthesis of Methoxy-, Methylenedioxy-, Hydroxy-, and Halo-Substituted Benzophenanthridinone Derivatives as DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors and Their Biological Activity for Drug-Resistant Cancer.

Hu DX, Tang WL, Zhang Y, Yang H, Wang W, Agama K, Pommier Y, An LK. Hu DX, et al. J Med Chem. 2021 Jun 10;64(11):7617-7629. doi: 10.1021/acs.jmedchem.1c00318. Epub 2021 May 19. J Med Chem. 2021. PMID: 34008967 Free PMC article.

9

Design, Synthesis and Cytotoxicity of Thiazole-Based Stilbene Analogs as Novel DNA Topoisomerase IB Inhibitors.

Liu JC, Chen B, Yang JL, Weng JQ, Yu Q, Hu DX. Liu JC, et al. Among authors: hu dx. Molecules. 2022 Feb 2;27(3):1009. doi: 10.3390/molecules27031009. Molecules. 2022. PMID: 35164276 Free PMC article.

10

Synthesis and Biological Activities of 11- and 12-Substituted Benzophenanthridinone Derivatives as DNA Topoisomerase IB and Tyrosyl-DNA Phosphodiesterase 1 Inhibitors.

Yang H, Qin C, Wu M, Wang FT, Wang W, Agama K, Pommier Y, Hu DX, An LK. Yang H, et al. Among authors: hu dx. ChemMedChem. 2023 May 16;18(10):e202200593. doi: 10.1002/cmdc.202200593. Epub 2023 Mar 17. ChemMedChem. 2023. PMID: 36932053 Free PMC article.

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