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Combined HDAC and Bromodomain Protein Inhibition Reprograms Tumor Cell Metabolism and Elicits Synthetic Lethality in Glioblastoma.
Zhang Y, Ishida CT, Ishida W, Lo SL, Zhao J, Shu C, Bianchetti E, Kleiner G, Sanchez-Quintero MJ, Quinzii CM, Westhoff MA, Karpel-Massler G, Canoll P, Siegelin MD. Zhang Y, et al. Clin Cancer Res. 2018 Aug 15;24(16):3941-3954. doi: 10.1158/1078-0432.CCR-18-0260. Epub 2018 May 15. Clin Cancer Res. 2018. PMID: 29764852 Free PMC article.
Metabolic Reprogramming by Dual AKT/ERK Inhibition through Imipridones Elicits Unique Vulnerabilities in Glioblastoma.
Ishida CT, Zhang Y, Bianchetti E, Shu C, Nguyen TTT, Kleiner G, Sanchez-Quintero MJ, Quinzii CM, Westhoff MA, Karpel-Massler G, Prabhu VV, Allen JE, Siegelin MD. Ishida CT, et al. Among authors: zhang y. Clin Cancer Res. 2018 Nov 1;24(21):5392-5406. doi: 10.1158/1078-0432.CCR-18-1040. Epub 2018 Jul 23. Clin Cancer Res. 2018. PMID: 30037819 Free PMC article.
A triple drug combination as a novel anti-glioma therapy?
Zhang Y, Karpel-Massler G, Siegelin MD. Zhang Y, et al. Oncotarget. 2018 Nov 6;9(87):35719-35720. doi: 10.18632/oncotarget.26279. eCollection 2018 Nov 6. Oncotarget. 2018. PMID: 30515262 Free PMC article. No abstract available.
MET Inhibition Elicits PGC1α-Dependent Metabolic Reprogramming in Glioblastoma.
Zhang Y, Nguyen TTT, Shang E, Mela A, Humala N, Mahajan A, Zhao J, Shu C, Torrini C, Sanchez-Quintero MJ, Kleiner G, Bianchetti E, Westhoff MA, Quinzii CM, Karpel-Massler G, Bruce JN, Canoll P, Siegelin MD. Zhang Y, et al. Cancer Res. 2020 Jan 1;80(1):30-43. doi: 10.1158/0008-5472.CAN-19-1389. Epub 2019 Nov 6. Cancer Res. 2020. PMID: 31694905 Free PMC article.
HDAC inhibitors elicit metabolic reprogramming by targeting super-enhancers in glioblastoma models.
Nguyen TTT, Zhang Y, Shang E, Shu C, Torrini C, Zhao J, Bianchetti E, Mela A, Humala N, Mahajan A, Harmanci AO, Lei Z, Maienschein-Cline M, Quinzii CM, Westhoff MA, Karpel-Massler G, Bruce JN, Canoll P, Siegelin MD. Nguyen TTT, et al. Among authors: zhang y. J Clin Invest. 2020 Jul 1;130(7):3699-3716. doi: 10.1172/JCI129049. J Clin Invest. 2020. PMID: 32315286 Free PMC article.
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