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Clotrimazole inhibits the Wnt/β-catenin pathway by activating two eIF2α kinases: The heme-regulated translational inhibitor and the double-stranded RNA-induced protein kinase.
Yonezawa H, Ogawa M, Katayama S, Shimizu Y, Omori N, Oku Y, Sakyo T, Uehara Y, Nishiya N. Yonezawa H, et al. Among authors: uehara y. Biochem Biophys Res Commun. 2018 Nov 17;506(1):183-188. doi: 10.1016/j.bbrc.2018.10.053. Epub 2018 Oct 17. Biochem Biophys Res Commun. 2018. PMID: 30342850
IMU1003, an atrarate derivative, inhibits Wnt/β-catenin signaling.
Yonezawa H, Sugawara A, Sakyo T, Uehara Y, Kawano T, Nishiya N. Yonezawa H, et al. Among authors: uehara y. Biochem Biophys Res Commun. 2020 Nov 12;532(3):440-445. doi: 10.1016/j.bbrc.2020.08.031. Epub 2020 Sep 3. Biochem Biophys Res Commun. 2020. PMID: 32891433
Ivermectin represses Wnt/β-catenin signaling by binding to TELO2, a regulator of phosphatidylinositol 3-kinase-related kinases.
Yonezawa H, Ikeda A, Takahashi R, Endo H, Sugawara Y, Goto M, Kanno M, Ogawa S, Nakamura K, Ujiie H, Iwatsuki M, Hirose T, Sunazuka T, Uehara Y, Nishiya N. Yonezawa H, et al. Among authors: uehara y. iScience. 2022 Mar 7;25(3):103912. doi: 10.1016/j.isci.2022.103912. eCollection 2022 Mar 18. iScience. 2022. PMID: 35530256 Free PMC article.
Lamellarin 14, a derivative of marine alkaloids, inhibits the T790M/C797S mutant epidermal growth factor receptor.
Nishiya N, Oku Y, Ishikawa C, Fukuda T, Dan S, Mashima T, Ushijima M, Furukawa Y, Sasaki Y, Otsu K, Sakyo T, Abe M, Yonezawa H, Ishibashi F, Matsuura M, Tomida A, Seimiya H, Yamori T, Iwao M, Uehara Y. Nishiya N, et al. Among authors: uehara y. Cancer Sci. 2021 May;112(5):1963-1974. doi: 10.1111/cas.14839. Epub 2021 Mar 24. Cancer Sci. 2021. PMID: 33544933 Free PMC article.
1,095 results