Nieman M - Search Results

1

The protease-activated receptor 4 Ala120Thr variant alters platelet responsiveness to low-dose thrombin and protease-activated receptor 4 desensitization, and is blocked by non-competitive P2Y₁₂ inhibition.

Whitley MJ, Henke DM, Ghazi A, Nieman M, Stoller M, Simon LM, Chen E, Vesci J, Holinstat M, McKenzie SE, Shaw CA, Edelstein LC, Bray PF. Whitley MJ, et al. Among authors: nieman m. J Thromb Haemost. 2018 Dec;16(12):2501-2514. doi: 10.1111/jth.14318. Epub 2018 Nov 22. J Thromb Haemost. 2018. PMID: 30347494 Free PMC article.

2

Elucidating the dynamics of Integrin αIIb[beta]3 from native platelet membranes by cryo-EM with build and retrieve method.

Han X, Zhang Z, Su CC, Lyu M, Miyagi M, Yu EW, Nieman MT. Han X, et al. Among authors: nieman mt. bioRxiv [Preprint]. 2024 Nov 27:2024.11.27.625729. doi: 10.1101/2024.11.27.625729. bioRxiv. 2024. PMID: 39651215 Free PMC article. Preprint.

3

Prothrombin Knockdown Protects Podocytes and Reduces Proteinuria in Glomerular Disease.

Waller AP, Wolfgang KJ, Pruner I, Stevenson ZS, Abdelghani E, Muralidharan K, Wilkie TK, Blissett AR, Calomeni EP, Vetter TA, Brodsky SV, Smoyer WE, Nieman MT, Kerlin BA. Waller AP, et al. bioRxiv [Preprint]. 2024 Mar 2:2023.06.20.544360. doi: 10.1101/2023.06.20.544360. bioRxiv. 2024. PMID: 38464017 Free PMC article. Preprint.

4

Mice with Reduced PAR4 Reactivity show Decreased Venous Thrombosis and Platelet Procoagulant Activity.

Knauss EA, Guci J, Luc N, Disharoon D, Huang GH, Gupta AS, Nieman MT. Knauss EA, et al. Among authors: nieman mt. bioRxiv [Preprint]. 2024 Oct 17:2024.10.14.617127. doi: 10.1101/2024.10.14.617127. bioRxiv. 2024. PMID: 39463946 Free PMC article. Preprint.

5

Thrombostatin FM compounds: direct thrombin inhibitors - mechanism of action in vitro and in vivo.

Nieman MT, Burke F, Warnock M, Zhou Y, Sweigart J, Chen A, Ricketts D, Lucchesi BR, Chen Z, Di Cera E, Hilfinger J, Kim JS, Mosberg HI, Schmaier AH. Nieman MT, et al. J Thromb Haemost. 2008 May;6(5):837-45. doi: 10.1111/j.1538-7836.2008.02937.x. Epub 2008 Feb 25. J Thromb Haemost. 2008. PMID: 18315550 Free PMC article.

6

Oral thrombostatin FM19 inhibits prostate cancer.

Nieman MT, LaRusch G, Fang C, Zhou Y, Schmaier AH. Nieman MT, et al. Thromb Haemost. 2010 Nov;104(5):1044-8. doi: 10.1160/TH09-08-0570. Epub 2010 Sep 30. Thromb Haemost. 2010. PMID: 20886199 Free PMC article.

7

Calcium mobilization and protein kinase C activation downstream of protease activated receptor 4 (PAR4) is negatively regulated by PAR3 in mouse platelets.

Arachiche A, de la Fuente M, Nieman MT. Arachiche A, et al. Among authors: nieman mt. PLoS One. 2013;8(2):e55740. doi: 10.1371/journal.pone.0055740. Epub 2013 Feb 6. PLoS One. 2013. PMID: 23405206 Free PMC article.

8

Protease-activated receptor 1 (PAR1) and PAR4 heterodimers are required for PAR1-enhanced cleavage of PAR4 by α-thrombin.

Arachiche A, Mumaw MM, de la Fuente M, Nieman MT. Arachiche A, et al. Among authors: nieman mt. J Biol Chem. 2013 Nov 8;288(45):32553-32562. doi: 10.1074/jbc.M113.472373. Epub 2013 Oct 4. J Biol Chem. 2013. PMID: 24097976 Free PMC article.

9

Targeting the anionic region of human protease-activated receptor 4 inhibits platelet aggregation and thrombosis without interfering with hemostasis.

Mumaw MM, de la Fuente M, Noble DN, Nieman MT. Mumaw MM, et al. Among authors: nieman mt. J Thromb Haemost. 2014 Aug;12(8):1331-41. doi: 10.1111/jth.12619. Epub 2014 Jun 27. J Thromb Haemost. 2014. PMID: 24888424 Free PMC article.

10

Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race.

Edelstein LC, Simon LM, Lindsay CR, Kong X, Teruel-Montoya R, Tourdot BE, Chen ES, Ma L, Coughlin S, Nieman M, Holinstat M, Shaw CA, Bray PF. Edelstein LC, et al. Among authors: nieman m. Blood. 2014 Nov 27;124(23):3450-8. doi: 10.1182/blood-2014-04-572479. Epub 2014 Oct 7. Blood. 2014. PMID: 25293779 Free PMC article.

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