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Information-Derived Mechanistic Hypotheses for Structural Cardiotoxicity.
Svensson F, Zoufir A, Mahmoud S, Afzal AM, Smit I, Giblin KA, Clements PJ, Mettetal JT, Pointon A, Harvey JS, Greene N, Williams RV, Bender A. Svensson F, et al. Among authors: clements pj. Chem Res Toxicol. 2018 Nov 19;31(11):1119-1127. doi: 10.1021/acs.chemrestox.8b00159. Epub 2018 Oct 17. Chem Res Toxicol. 2018. PMID: 30350600
Physiological, pharmacological and toxicological considerations of drug-induced structural cardiac injury.
Cross MJ, Berridge BR, Clements PJ, Cove-Smith L, Force TL, Hoffmann P, Holbrook M, Lyon AR, Mellor HR, Norris AA, Pirmohamed M, Tugwood JD, Sidaway JE, Park BK. Cross MJ, et al. Among authors: clements pj. Br J Pharmacol. 2015 Feb;172(4):957-74. doi: 10.1111/bph.12979. Epub 2015 Jan 12. Br J Pharmacol. 2015. PMID: 25302413 Free PMC article. Review.
Unlocking Personalized Biomedicine and Drug Discovery with Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Fit for Purpose or Forever Elusive?
de Korte T, Katili PA, Mohd Yusof NAN, van Meer BJ, Saleem U, Burton FL, Smith GL, Clements P, Mummery CL, Eschenhagen T, Hansen A, Denning C. de Korte T, et al. Annu Rev Pharmacol Toxicol. 2020 Jan 6;60:529-551. doi: 10.1146/annurev-pharmtox-010919-023309. Epub 2019 Sep 10. Annu Rev Pharmacol Toxicol. 2020. PMID: 31506008 Review.
Blinded, Multicenter Evaluation of Drug-induced Changes in Contractility Using Human-induced Pluripotent Stem Cell-derived Cardiomyocytes.
Saleem U, van Meer BJ, Katili PA, Mohd Yusof NAN, Mannhardt I, Garcia AK, Tertoolen L, de Korte T, Vlaming MLH, McGlynn K, Nebel J, Bahinski A, Harris K, Rossman E, Xu X, Burton FL, Smith GL, Clements P, Mummery CL, Eschenhagen T, Hansen A, Denning C. Saleem U, et al. Toxicol Sci. 2020 Jul 1;176(1):103-123. doi: 10.1093/toxsci/kfaa058. Toxicol Sci. 2020. PMID: 32421822 Free PMC article.
Evaluating Associations Between Nonclinical Cardiovascular Functional Endpoints and Repeat-dose Cardiovascular Toxicity in the Beagle Dog: A Cross-company Initiative.
Milliken P, Aylott M, Edmunds N, Engle S, Ewart L, Fleurance R, Guffroy M, Hargreaves A, Heinz-Taheny K, Kirk S, Leishman D, Leong L, McMahon N, Valentin JP, Watson D, Wallis R, Clements P. Milliken P, et al. Toxicol Sci. 2020 Jul 1;176(1):224-235. doi: 10.1093/toxsci/kfaa051. Toxicol Sci. 2020. PMID: 32298455
208 results