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Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties.
Cao L, Weetall M, Trotta C, Cintron K, Ma J, Kim MJ, Furia B, Romfo C, Graci JD, Li W, Du J, Sheedy J, Hedrick J, Risher N, Yeh S, Qi H, Arasu T, Hwang S, Lennox W, Kong R, Petruska J, Moon YC, Babiak J, Davis TW, Jacobson A, Almstead NG, Branstrom A, Colacino JM, Peltz SW. Cao L, et al. Among authors: jacobson a. Mol Cancer Ther. 2019 Jan;18(1):3-16. doi: 10.1158/1535-7163.MCT-18-0863. Epub 2018 Oct 23. Mol Cancer Ther. 2019. PMID: 30352802 Free PMC article.
Turnover of mRNA in prokaryotes and lower eukaryotes.
Higgins CF, Peltz SW, Jacobson A. Higgins CF, et al. Among authors: jacobson a. Curr Opin Genet Dev. 1992 Oct;2(5):739-47. doi: 10.1016/s0959-437x(05)80134-0. Curr Opin Genet Dev. 1992. PMID: 1281028 Review.
A mutation in the tRNA nucleotidyltransferase gene promotes stabilization of mRNAs in Saccharomyces cerevisiae.
Peltz SW, Donahue JL, Jacobson A. Peltz SW, et al. Among authors: jacobson a. Mol Cell Biol. 1992 Dec;12(12):5778-84. doi: 10.1128/mcb.12.12.5778-5784.1992. Mol Cell Biol. 1992. PMID: 1448105 Free PMC article.
To identify trans-acting factors involved in mRNA decay in the yeast Saccharomyces cerevisiae, we have begun to characterize conditional lethal mutants that affect mRNA steady-state levels. A screen of a collection of temperature-sensitive mutants identified ts352, …
To identify trans-acting factors involved in mRNA decay in the yeast Saccharomyces cerevisiae, we have begun to characterize conditional let …
mRNA stability: in trans-it.
Peltz SW, Jacobson A. Peltz SW, et al. Among authors: jacobson a. Curr Opin Cell Biol. 1992 Dec;4(6):979-83. doi: 10.1016/0955-0674(92)90129-z. Curr Opin Cell Biol. 1992. PMID: 1485969 Review.
Nonsense-mediated mRNA decay in yeast.
Peltz SW, He F, Welch E, Jacobson A. Peltz SW, et al. Among authors: jacobson a. Prog Nucleic Acid Res Mol Biol. 1994;47:271-98. doi: 10.1016/s0079-6603(08)60254-8. Prog Nucleic Acid Res Mol Biol. 1994. PMID: 8016322 Review. No abstract available.
PTC124 targets genetic disorders caused by nonsense mutations.
Welch EM, Barton ER, Zhuo J, Tomizawa Y, Friesen WJ, Trifillis P, Paushkin S, Patel M, Trotta CR, Hwang S, Wilde RG, Karp G, Takasugi J, Chen G, Jones S, Ren H, Moon YC, Corson D, Turpoff AA, Campbell JA, Conn MM, Khan A, Almstead NG, Hedrick J, Mollin A, Risher N, Weetall M, Yeh S, Branstrom AA, Colacino JM, Babiak J, Ju WD, Hirawat S, Northcutt VJ, Miller LL, Spatrick P, He F, Kawana M, Feng H, Jacobson A, Peltz SW, Sweeney HL. Welch EM, et al. Among authors: jacobson a. Nature. 2007 May 3;447(7140):87-91. doi: 10.1038/nature05756. Epub 2007 Apr 22. Nature. 2007. PMID: 17450125
1,794 results