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Page 1
Total Synthesis of Glycosylated Human Interferon-γ.
Wang X, Ashhurst AS, Dowman LJ, Watson EE, Li HY, Fairbanks AJ, Larance M, Kwan A, Payne RJ. Wang X, et al. Among authors: ashhurst as. Org Lett. 2020 Sep 4;22(17):6863-6867. doi: 10.1021/acs.orglett.0c02401. Epub 2020 Aug 24. Org Lett. 2020. PMID: 32830985
Human anogenital monocyte-derived dendritic cells and langerin+cDC2 are major HIV target cells.
Rhodes JW, Botting RA, Bertram KM, Vine EE, Rana H, Baharlou H, Vegh P, O'Neil TR, Ashhurst AS, Fletcher J, Parnell GP, Graham JD, Nasr N, Lim JJK, Barnouti L, Haertsch P, Gosselink MP, Di Re A, Reza F, Ctercteko G, Jenkins GJ, Brooks AJ, Patrick E, Byrne SN, Hunter E, Haniffa MA, Cunningham AL, Harman AN. Rhodes JW, et al. Among authors: ashhurst as. Nat Commun. 2021 Apr 12;12(1):2147. doi: 10.1038/s41467-021-22375-x. Nat Commun. 2021. PMID: 33846309 Free PMC article.
Potent Cyclic Peptide Inhibitors of FXIIa Discovered by mRNA Display with Genetic Code Reprogramming.
Ford DJ, Duggan NM, Fry SE, Ripoll-Rozada J, Agten SM, Liu W, Corcilius L, Hackeng TM, van Oerle R, Spronk HMH, Ashhurst AS, Mini Sasi V, Kaczmarski JA, Jackson CJ, Pereira PJB, Passioura T, Suga H, Payne RJ. Ford DJ, et al. Among authors: ashhurst as. J Med Chem. 2021 Jun 10;64(11):7853-7876. doi: 10.1021/acs.jmedchem.1c00651. Epub 2021 May 27. J Med Chem. 2021. PMID: 34044534
Discovery of Cyclic Peptide Ligands to the SARS-CoV-2 Spike Protein Using mRNA Display.
Norman A, Franck C, Christie M, Hawkins PME, Patel K, Ashhurst AS, Aggarwal A, Low JKK, Siddiquee R, Ashley CL, Steain M, Triccas JA, Turville S, Mackay JP, Passioura T, Payne RJ. Norman A, et al. Among authors: ashhurst as. ACS Cent Sci. 2021 Jun 23;7(6):1001-1008. doi: 10.1021/acscentsci.0c01708. Epub 2021 May 27. ACS Cent Sci. 2021. PMID: 34230894 Free PMC article.
Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L.
Ashhurst AS, Tang AH, Fajtová P, Yoon MC, Aggarwal A, Bedding MJ, Stoye A, Beretta L, Pwee D, Drelich A, Skinner D, Li L, Meek TD, McKerrow JH, Hook V, Tseng CT, Larance M, Turville S, Gerwick WH, O'Donoghue AJ, Payne RJ. Ashhurst AS, et al. J Med Chem. 2022 Feb 24;65(4):2956-2970. doi: 10.1021/acs.jmedchem.1c01494. Epub 2021 Nov 3. J Med Chem. 2022. PMID: 34730959 Free PMC article.
GRAPPA 2020 Research Award Recipients.
Castillo RL, Yan D, Ashhurst AS, Elliott A, Angioni MM, Scher JU, Naik S, Neimann A, Byrne SN, Payne RJ, FitzGerald O, Pennington SR, Cauli A, Chandran V. Castillo RL, et al. Among authors: ashhurst as. J Rheumatol. 2022 Jun;49(6 Suppl 1):55-56. doi: 10.3899/jrheum.211335. Epub 2022 Mar 15. J Rheumatol. 2022. PMID: 35293338 Free PMC article.
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