Yang P - Search Results

1

4-Iminooxazolidin-2-one as a Bioisostere of the Cyanohydrin Moiety: Inhibitors of Enterovirus 71 3C Protease.

Ma Y, Shang C, Yang P, Li L, Zhai Y, Yin Z, Wang B, Shang L. Ma Y, et al. Among authors: yang p. J Med Chem. 2018 Nov 21;61(22):10333-10339. doi: 10.1021/acs.jmedchem.8b01335. Epub 2018 Nov 8. J Med Chem. 2018. PMID: 30365311

2

Novel triaryl sulfonamide derivatives as selective cannabinoid receptor 2 inverse agonists and osteoclast inhibitors: discovery, optimization, and biological evaluation.

Yang P, Wang L, Feng R, Almehizia AA, Tong Q, Myint KZ, Ouyang Q, Alqarni MH, Wang L, Xie XQ. Yang P, et al. J Med Chem. 2013 Mar 14;56(5):2045-58. doi: 10.1021/jm3017464. Epub 2013 Mar 1. J Med Chem. 2013. PMID: 23406429 Free PMC article.

3

Discovery of novel and selective CDK4/6 inhibitors by pharmacophore and structure-based virtual screening.

Yuan K, Min W, Wang X, Li J, Kuang W, Zhang F, Xie S, Yang P. Yuan K, et al. Among authors: yang p. Future Med Chem. 2020 Jun;12(12):1121-1136. doi: 10.4155/fmc-2020-0011. Epub 2020 May 13. Future Med Chem. 2020. PMID: 32400188

4

Design, Synthesis, and Biological Evaluation of Icaritin Derivatives as Novel Putative DEPTOR Inhibitors for Multiple Myeloma Treatment.

Hou Y, Kuang W, Min W, Liu Z, Zhang F, Yuan K, Wang X, Sun C, Cheng H, Wang L, Xiao Y, Pu S, Xin GZ, Yang P. Hou Y, et al. Among authors: yang p. J Med Chem. 2021 Oct 28;64(20):14942-14954. doi: 10.1021/acs.jmedchem.1c00087. Epub 2021 Oct 13. J Med Chem. 2021. PMID: 34644502

5

Discovery of novel and orally bioavailable CDK 4/6 inhibitors with high kinome selectivity, low toxicity and long-acting stability for the treatment of multiple myeloma.

Yuan K, Kuang W, Chen W, Ji M, Min W, Zhu Y, Hou Y, Wang X, Li J, Wang L, Yang P. Yuan K, et al. Among authors: yang p. Eur J Med Chem. 2022 Jan 15;228:114024. doi: 10.1016/j.ejmech.2021.114024. Epub 2021 Nov 29. Eur J Med Chem. 2022. PMID: 34875521

6

Discovery of Dual CDK6/PIM1 Inhibitors with a Novel Structure, High Potency, and Favorable Druggability for the Treatment of Acute Myeloid Leukemia.

Yuan K, Ji M, Xie S, Qiu Z, Chen W, Min W, Xia F, Zheng M, Wang X, Li J, Hou Y, Kuang W, Wang L, Gu W, Li Z, Yang P. Yuan K, et al. Among authors: yang p. J Med Chem. 2022 Jan 13;65(1):857-875. doi: 10.1021/acs.jmedchem.1c02019. Epub 2021 Dec 27. J Med Chem. 2022. PMID: 34958208

7

Discovery of Novel Phosphoinositide-3-Kinase α Inhibitors with High Selectivity, Excellent Bioavailability, and Long-Acting Efficacy for Gastric Cancer.

Hou Y, Zhang F, Min W, Yuan K, Kuang W, Wang X, Zhu Y, Sun C, Xia F, Wang Y, Zhang H, Wang L, Yang P. Hou Y, et al. Among authors: yang p. J Med Chem. 2022 Jul 28;65(14):9873-9892. doi: 10.1021/acs.jmedchem.2c00549. Epub 2022 Jul 14. J Med Chem. 2022. PMID: 35834807

8

Discovery, Optimization, and Evaluation of Selective CDK4/6 Inhibitors for the Treatment of Breast Cancer.

Chen W, Ji M, Cheng H, Zheng M, Xia F, Min W, Yang H, Wang X, Wang L, Cao L, Yuan K, Yang P. Chen W, et al. Among authors: yang p, yang h. J Med Chem. 2022 Nov 24;65(22):15102-15122. doi: 10.1021/acs.jmedchem.2c00947. Epub 2022 Nov 9. J Med Chem. 2022. PMID: 36350721

9

Novel Small-Molecule PD-L1 Inhibitor Induces PD-L1 Internalization and Optimizes the Immune Microenvironment.

Sun C, Yin M, Cheng Y, Kuang Z, Liu X, Wang G, Wang X, Yuan K, Min W, Dong J, Hou Y, Hu L, Zhang G, Pei W, Wang L, Sun Y, Yu X, Xiao Y, Deng H, Yang P. Sun C, et al. Among authors: yang p. J Med Chem. 2023 Feb 9;66(3):2064-2083. doi: 10.1021/acs.jmedchem.2c01801. Epub 2022 Dec 29. J Med Chem. 2023. PMID: 36579489

10

Discovery of Potent DYRK2 Inhibitors with High Selectivity, Great Solubility, and Excellent Safety Properties for the Treatment of Prostate Cancer.

Yuan K, Shen H, Zheng M, Xia F, Li Q, Chen W, Ji M, Yang H, Zhuang X, Cai Z, Min W, Wang X, Xiao Y, Yang P. Yuan K, et al. Among authors: yang p, yang h. J Med Chem. 2023 Mar 23;66(6):4215-4230. doi: 10.1021/acs.jmedchem.3c00106. Epub 2023 Feb 17. J Med Chem. 2023. PMID: 36800260

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