Lal A - Search Results

1

Multi-omic tumor data reveal diversity of molecular mechanisms that correlate with survival.

Ramazzotti D, Lal A, Wang B, Batzoglou S, Sidow A. Ramazzotti D, et al. Among authors: lal a. Nat Commun. 2018 Oct 26;9(1):4453. doi: 10.1038/s41467-018-06921-8. Nat Commun. 2018. PMID: 30367051 Free PMC article.

2

Comprehensive genomic characterization of breast tumors with BRCA1 and BRCA2 mutations.

Lal A, Ramazzotti D, Weng Z, Liu K, Ford JM, Sidow A. Lal A, et al. BMC Med Genomics. 2019 Jun 10;12(1):84. doi: 10.1186/s12920-019-0545-0. BMC Med Genomics. 2019. PMID: 31182087 Free PMC article.

3

De novo mutational signature discovery in tumor genomes using SparseSignatures.

Lal A, Liu K, Tibshirani R, Sidow A, Ramazzotti D. Lal A, et al. PLoS Comput Biol. 2021 Jun 28;17(6):e1009119. doi: 10.1371/journal.pcbi.1009119. eCollection 2021 Jun. PLoS Comput Biol. 2021. PMID: 34181655 Free PMC article.

4

SparseSignatures: An R package using LASSO-regularized non-negative matrix factorization to identify mutational signatures from human tumor samples.

Mella L, Lal A, Angaroni F, Maspero D, Piazza R, Sidow A, Antoniotti M, Graudenzi A, Ramazzotti D. Mella L, et al. Among authors: lal a. STAR Protoc. 2022 Sep 16;3(3):101513. doi: 10.1016/j.xpro.2022.101513. Epub 2022 Jul 1. STAR Protoc. 2022. PMID: 35779264 Free PMC article.

We describe installation details and illustrate a step-by-step approach to (1) prepare the data for signature analysis, (2) determine the optimal parameters, and (3) employ them to determine the signatures and related exposure levels in the point mutation dataset. For comp …

We describe installation details and illustrate a step-by-step approach to (1) prepare the data for signature analysis, (2) determine …

5

Deep learning-based enhancement of epigenomics data with AtacWorks.

Lal A, Chiang ZD, Yakovenko N, Duarte FM, Israeli J, Buenrostro JD. Lal A, et al. Nat Commun. 2021 Mar 8;12(1):1507. doi: 10.1038/s41467-021-21765-5. Nat Commun. 2021. PMID: 33686069 Free PMC article.

6

Genome scale patterns of supercoiling in a bacterial chromosome.

Lal A, Dhar A, Trostel A, Kouzine F, Seshasayee AS, Adhya S. Lal A, et al. Nat Commun. 2016 Mar 30;7:11055. doi: 10.1038/ncomms11055. Nat Commun. 2016. PMID: 27025941 Free PMC article.

7

Genome-wide bioinformatic analyses predict key host and viral factors in SARS-CoV-2 pathogenesis.

Ferrarini MG, Lal A, Rebollo R, Gruber AJ, Guarracino A, Gonzalez IM, Floyd T, de Oliveira DS, Shanklin J, Beausoleil E, Pusa T, Pickett BE, Aguiar-Pulido V. Ferrarini MG, et al. Among authors: lal a. Commun Biol. 2021 May 17;4(1):590. doi: 10.1038/s42003-021-02095-0. Commun Biol. 2021. PMID: 34002013 Free PMC article.

8

Bundle compliance patterns in septic shock and their association with patient outcomes: an unsupervised cluster analysis.

Tekin A, Mosolygó B, Huo N, Xiao G, Lal A. Tekin A, et al. Among authors: lal a. Intern Emerg Med. 2024 Dec 12. doi: 10.1007/s11739-024-03836-9. Online ahead of print. Intern Emerg Med. 2024. PMID: 39663293

9

Nickel-oxide embedded laser-induced graphene for high-performance supercapacitors.

Porat H, Lal A, Dutta A, Yadav MK, Sesu DC, Minnes R, Borenstein A. Porat H, et al. Among authors: lal a. Nanoscale. 2024 Dec 11. doi: 10.1039/d4nr03227f. Online ahead of print. Nanoscale. 2024. PMID: 39661053

10

The Ongoing Pursuit to Reduce the Burden of IV Vasopressor Infusions.

Wieruszewski PM, Lal A. Wieruszewski PM, et al. Among authors: lal a. Crit Care Med. 2024 Dec 4. doi: 10.1097/CCM.0000000000006531. Online ahead of print. Crit Care Med. 2024. PMID: 39656499 No abstract available.

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