Pai EF - Search Results

1

The hit-and-return system enables efficient time-resolved serial synchrotron crystallography.

Schulz EC, Mehrabi P, Müller-Werkmeister HM, Tellkamp F, Jha A, Stuart W, Persch E, De Gasparo R, Diederich F, Pai EF, Miller RJD. Schulz EC, et al. Among authors: pai ef. Nat Methods. 2018 Nov;15(11):901-904. doi: 10.1038/s41592-018-0180-2. Epub 2018 Oct 30. Nat Methods. 2018. PMID: 30377366

2

Time-resolved crystallography reveals allosteric communication aligned with molecular breathing.

Mehrabi P, Schulz EC, Dsouza R, Müller-Werkmeister HM, Tellkamp F, Miller RJD, Pai EF. Mehrabi P, et al. Among authors: pai ef. Science. 2019 Sep 13;365(6458):1167-1170. doi: 10.1126/science.aaw9904. Science. 2019. PMID: 31515393

3

Serial femtosecond and serial synchrotron crystallography can yield data of equivalent quality: A systematic comparison.

Mehrabi P, Bücker R, Bourenkov G, Ginn HM, von Stetten D, Müller-Werkmeister HM, Kuo A, Morizumi T, Eger BT, Ou WL, Oghbaey S, Sarracini A, Besaw JE, Pare-Labrosse O, Meier S, Schikora H, Tellkamp F, Marx A, Sherrell DA, Axford D, Owen RL, Ernst OP, Pai EF, Schulz EC, Miller RJD. Mehrabi P, et al. Among authors: pai ef. Sci Adv. 2021 Mar 17;7(12):eabf1380. doi: 10.1126/sciadv.abf1380. Print 2021 Mar. Sci Adv. 2021. PMID: 33731353 Free PMC article.

4

Targeting a Large Active Site: Structure-Based Design of Nanomolar Inhibitors of Trypanosoma brucei Trypanothione Reductase.

De Gasparo R, Halgas O, Harangozo D, Kaiser M, Pai EF, Krauth-Siegel RL, Diederich F. De Gasparo R, et al. Among authors: pai ef. Chemistry. 2019 Sep 2;25(49):11416-11421. doi: 10.1002/chem.201901664. Epub 2019 Aug 13. Chemistry. 2019. PMID: 31407832

5

The role of dimer asymmetry and protomer dynamics in enzyme catalysis.

Kim TH, Mehrabi P, Ren Z, Sljoka A, Ing C, Bezginov A, Ye L, Pomès R, Prosser RS, Pai EF. Kim TH, et al. Among authors: pai ef. Science. 2017 Jan 20;355(6322):eaag2355. doi: 10.1126/science.aag2355. Science. 2017. PMID: 28104837

6

Substrate-Based Allosteric Regulation of a Homodimeric Enzyme.

Mehrabi P, Di Pietrantonio C, Kim TH, Sljoka A, Taverner K, Ing C, Kruglyak N, Pomès R, Pai EF, Prosser RS. Mehrabi P, et al. Among authors: pai ef. J Am Chem Soc. 2019 Jul 24;141(29):11540-11556. doi: 10.1021/jacs.9b03703. Epub 2019 Jun 26. J Am Chem Soc. 2019. PMID: 31188575

7

Biological Evaluation and X-ray Co-crystal Structures of Cyclohexylpyrrolidine Ligands for Trypanothione Reductase, an Enzyme from the Redox Metabolism of Trypanosoma.

De Gasparo R, Brodbeck-Persch E, Bryson S, Hentzen NB, Kaiser M, Pai EF, Krauth-Siegel RL, Diederich F. De Gasparo R, et al. Among authors: pai ef. ChemMedChem. 2018 May 8;13(9):957-967. doi: 10.1002/cmdc.201800067. Epub 2018 Apr 6. ChemMedChem. 2018. PMID: 29624890

8

Binding to large enzyme pockets: small-molecule inhibitors of trypanothione reductase.

Persch E, Bryson S, Todoroff NK, Eberle C, Thelemann J, Dirdjaja N, Kaiser M, Weber M, Derbani H, Brun R, Schneider G, Pai EF, Krauth-Siegel RL, Diederich F. Persch E, et al. Among authors: pai ef. ChemMedChem. 2014 Aug;9(8):1880-91. doi: 10.1002/cmdc.201402032. Epub 2014 Apr 30. ChemMedChem. 2014. PMID: 24788386

9

Time-resolved X-ray crystallographic study of the conformational change in Ha-Ras p21 protein on GTP hydrolysis.

Schlichting I, Almo SC, Rapp G, Wilson K, Petratos K, Lentfer A, Wittinghofer A, Kabsch W, Pai EF, Petsko GA, et al. Schlichting I, et al. Among authors: pai ef. Nature. 1990 May 24;345(6273):309-15. doi: 10.1038/345309a0. Nature. 1990. PMID: 2111463

10

Structural proteomics of an archaeon.

Christendat D, Yee A, Dharamsi A, Kluger Y, Savchenko A, Cort JR, Booth V, Mackereth CD, Saridakis V, Ekiel I, Kozlov G, Maxwell KL, Wu N, McIntosh LP, Gehring K, Kennedy MA, Davidson AR, Pai EF, Gerstein M, Edwards AM, Arrowsmith CH. Christendat D, et al. Among authors: pai ef. Nat Struct Biol. 2000 Oct;7(10):903-9. doi: 10.1038/82823. Nat Struct Biol. 2000. PMID: 11017201

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