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The colibactin warhead crosslinks DNA.
Vizcaino MI, Crawford JM. Vizcaino MI, et al. Among authors: crawford jm. Nat Chem. 2015 May;7(5):411-7. doi: 10.1038/nchem.2221. Epub 2015 Apr 6. Nat Chem. 2015. PMID: 25901819 Free PMC article.
A Mechanistic Model for Colibactin-Induced Genotoxicity.
Healy AR, Nikolayevskiy H, Patel JR, Crawford JM, Herzon SB. Healy AR, et al. Among authors: crawford jm. J Am Chem Soc. 2016 Dec 7;138(48):15563-15570. doi: 10.1021/jacs.6b10354. Epub 2016 Nov 28. J Am Chem Soc. 2016. PMID: 27934011 Free PMC article.
ClbS Is a Cyclopropane Hydrolase That Confers Colibactin Resistance.
Tripathi P, Shine EE, Healy AR, Kim CS, Herzon SB, Bruner SD, Crawford JM. Tripathi P, et al. Among authors: crawford jm. J Am Chem Soc. 2017 Dec 13;139(49):17719-17722. doi: 10.1021/jacs.7b09971. Epub 2017 Nov 28. J Am Chem Soc. 2017. PMID: 29112397 Free PMC article.
β-Lactam Biotransformations Activate Innate Immunity.
Oh J, Patel J, Park HB, Crawford JM. Oh J, et al. Among authors: crawford jm. J Org Chem. 2018 Jul 6;83(13):7173-7179. doi: 10.1021/acs.joc.8b00241. Epub 2018 Apr 10. J Org Chem. 2018. PMID: 29616809
506 results