Walsh DM - Search Results

1

Learnings about the complexity of extracellular tau aid development of a blood-based screen for Alzheimer's disease.

Chen Z, Mengel D, Keshavan A, Rissman RA, Billinton A, Perkinton M, Percival-Alwyn J, Schultz A, Properzi M, Johnson K, Selkoe DJ, Sperling RA, Patel P, Zetterberg H, Galasko D, Schott JM, Walsh DM. Chen Z, et al. Among authors: walsh dm. Alzheimers Dement. 2019 Mar;15(3):487-496. doi: 10.1016/j.jalz.2018.09.010. Epub 2018 Nov 9. Alzheimers Dement. 2019. PMID: 30419228 Free PMC article.

2

Oligomerization of endogenous and synthetic amyloid beta-protein at nanomolar levels in cell culture and stabilization of monomer by Congo red.

Podlisny MB, Walsh DM, Amarante P, Ostaszewski BL, Stimson ER, Maggio JE, Teplow DB, Selkoe DJ. Podlisny MB, et al. Among authors: walsh dm. Biochemistry. 1998 Mar 17;37(11):3602-11. doi: 10.1021/bi972029u. Biochemistry. 1998. PMID: 9521679

3

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation.

Qiu WQ, Walsh DM, Ye Z, Vekrellis K, Zhang J, Podlisny MB, Rosner MR, Safavi A, Hersh LB, Selkoe DJ. Qiu WQ, et al. Among authors: walsh dm. J Biol Chem. 1998 Dec 4;273(49):32730-8. doi: 10.1074/jbc.273.49.32730. J Biol Chem. 1998. PMID: 9830016 Free article.

4

Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates.

Walsh DM, Hartley DM, Kusumoto Y, Fezoui Y, Condron MM, Lomakin A, Benedek GB, Selkoe DJ, Teplow DB. Walsh DM, et al. J Biol Chem. 1999 Sep 3;274(36):25945-52. doi: 10.1074/jbc.274.36.25945. J Biol Chem. 1999. PMID: 10464339 Free article.

5

Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.

Hartley DM, Walsh DM, Ye CP, Diehl T, Vasquez S, Vassilev PM, Teplow DB, Selkoe DJ. Hartley DM, et al. Among authors: walsh dm. J Neurosci. 1999 Oct 15;19(20):8876-84. doi: 10.1523/JNEUROSCI.19-20-08876.1999. J Neurosci. 1999. PMID: 10516307 Free PMC article.

6

Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme.

Vekrellis K, Ye Z, Qiu WQ, Walsh D, Hartley D, Chesneau V, Rosner MR, Selkoe DJ. Vekrellis K, et al. J Neurosci. 2000 Mar 1;20(5):1657-65. doi: 10.1523/JNEUROSCI.20-05-01657.2000. J Neurosci. 2000. PMID: 10684867 Free PMC article.

7

The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain.

Walsh DM, Tseng BP, Rydel RE, Podlisny MB, Selkoe DJ. Walsh DM, et al. Biochemistry. 2000 Sep 5;39(35):10831-9. doi: 10.1021/bi001048s. Biochemistry. 2000. PMID: 10978169

8

An improved method of preparing the amyloid beta-protein for fibrillogenesis and neurotoxicity experiments.

Fezoui Y, Hartley DM, Harper JD, Khurana R, Walsh DM, Condron MM, Selkoe DJ, Lansbury PT Jr, Fink AL, Teplow DB. Fezoui Y, et al. Among authors: walsh dm. Amyloid. 2000 Sep;7(3):166-78. doi: 10.3109/13506120009146831. Amyloid. 2000. PMID: 11019857

9

A de novo designed helix-turn-helix peptide forms nontoxic amyloid fibrils.

Fezoui Y, Hartley DM, Walsh DM, Selkoe DJ, Osterhout JJ, Teplow DB. Fezoui Y, et al. Among authors: walsh dm. Nat Struct Biol. 2000 Dec;7(12):1095-9. doi: 10.1038/81937. Nat Struct Biol. 2000. PMID: 11101888

10

In vitro studies of amyloid beta-protein fibril assembly and toxicity provide clues to the aetiology of Flemish variant (Ala692-->Gly) Alzheimer's disease.

Walsh DM, Hartley DM, Condron MM, Selkoe DJ, Teplow DB. Walsh DM, et al. Biochem J. 2001 May 1;355(Pt 3):869-77. doi: 10.1042/bj3550869. Biochem J. 2001. PMID: 11311152 Free PMC article.

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