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Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents.
Brindisi M, Ulivieri C, Alfano G, Gemma S, de Asís Balaguer F, Khan T, Grillo A, Chemi G, Menchon G, Prota AE, Olieric N, Lucena-Agell D, Barasoain I, Diaz JF, Nebbioso A, Conte M, Lopresti L, Magnano S, Amet R, Kinsella P, Zisterer DM, Ibrahim O, O'Sullivan J, Morbidelli L, Spaccapelo R, Baldari C, Butini S, Novellino E, Campiani G, Altucci L, Steinmetz MO, Brogi S. Brindisi M, et al. Among authors: barasoain i. Eur J Med Chem. 2019 Jan 15;162:290-320. doi: 10.1016/j.ejmech.2018.11.004. Epub 2018 Nov 3. Eur J Med Chem. 2019. PMID: 30448418
Fluorescent taxoid probes for microtubule research.
Barasoain I, Díaz JF, Andreu JM. Barasoain I, et al. Methods Cell Biol. 2010;95:353-72. doi: 10.1016/S0091-679X(10)95019-X. Methods Cell Biol. 2010. PMID: 20466144 Review.
Triazolopyrimidines Are Microtubule-Stabilizing Agents that Bind the Vinca Inhibitor Site of Tubulin.
Sáez-Calvo G, Sharma A, Balaguer FA, Barasoain I, Rodríguez-Salarichs J, Olieric N, Muñoz-Hernández H, Berbís MÁ, Wendeborn S, Peñalva MA, Matesanz R, Canales Á, Prota AE, Jímenez-Barbero J, Andreu JM, Lamberth C, Steinmetz MO, Díaz JF. Sáez-Calvo G, et al. Among authors: barasoain i. Cell Chem Biol. 2017 Jun 22;24(6):737-750.e6. doi: 10.1016/j.chembiol.2017.05.016. Epub 2017 Jun 1. Cell Chem Biol. 2017. PMID: 28579361 Free article.
Modification of C-seco taxoids through ring tethering and substituent replacement leading to effective agents against tumor drug resistance mediated by βIII-Tubulin and P-glycoprotein (P-gp) overexpressions.
Tang Y, Rodríguez-Salarichs J, Zhao Y, Cai P, Estévez-Gallego J, Balaguer-Pérez F, Redondo Horcajo M, Lucena-Agell D, Barasoain I, Díaz JF, Fang WS. Tang Y, et al. Among authors: barasoain i. Eur J Med Chem. 2017 Sep 8;137:488-503. doi: 10.1016/j.ejmech.2017.06.001. Epub 2017 Jun 3. Eur J Med Chem. 2017. PMID: 28624703
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.
Matesanz R, Trigili C, Rodríguez-Salarichs J, Zanardi I, Pera B, Nogales A, Fang WS, Jímenez-Barbero J, Canales A, Barasoain I, Ojima I, Díaz JF. Matesanz R, et al. Among authors: barasoain i. Bioorg Med Chem. 2014 Sep 15;22(18):5078-90. doi: 10.1016/j.bmc.2014.05.048. Epub 2014 Jun 19. Bioorg Med Chem. 2014. PMID: 25047938 Free article.
92 results