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Endothelial Dimethylarginine Dimethylaminohydrolase 1 Is an Important Regulator of Angiogenesis but Does Not Regulate Vascular Reactivity or Hemodynamic Homeostasis.
Dowsett L, Piper S, Slaviero A, Dufton N, Wang Z, Boruc O, Delahaye M, Colman L, Kalk E, Tomlinson J, Birdsey G, Randi AM, Leiper J. Dowsett L, et al. Among authors: leiper j. Circulation. 2015 Jun 23;131(25):2217-25. doi: 10.1161/CIRCULATIONAHA.114.015064. Epub 2015 Apr 24. Circulation. 2015. PMID: 25910799
Metabolomic profiling of amines in sepsis predicts changes in NOS canonical pathways.
Tesfai A, MacCallum N, Kirkby NS, Gashaw H, Gray N, Want E, Quinlan GJ, Mumby S, Leiper JM, Paul-Clark M, Ahmetaj-Shala B, Mitchell JA. Tesfai A, et al. Among authors: leiper jm. PLoS One. 2017 Aug 15;12(8):e0183025. doi: 10.1371/journal.pone.0183025. eCollection 2017. PLoS One. 2017. PMID: 28813479 Free PMC article.
Alanine-glyoxylate aminotransferase-2 metabolizes endogenous methylarginines, regulates NO, and controls blood pressure.
Caplin B, Wang Z, Slaviero A, Tomlinson J, Dowsett L, Delahaye M, Salama A; International Consortium for Blood Pressure Genome-Wide Association Studies; Wheeler DC, Leiper J. Caplin B, et al. Among authors: leiper j. Arterioscler Thromb Vasc Biol. 2012 Dec;32(12):2892-900. doi: 10.1161/ATVBAHA.112.254078. Epub 2012 Sep 27. Arterioscler Thromb Vasc Biol. 2012. PMID: 23023372
Asymmetric dimethylarginine causes hypertension and cardiac dysfunction in humans and is actively metabolized by dimethylarginine dimethylaminohydrolase.
Achan V, Broadhead M, Malaki M, Whitley G, Leiper J, MacAllister R, Vallance P. Achan V, et al. Among authors: leiper j. Arterioscler Thromb Vasc Biol. 2003 Aug 1;23(8):1455-9. doi: 10.1161/01.ATV.0000081742.92006.59. Epub 2003 Jun 12. Arterioscler Thromb Vasc Biol. 2003. PMID: 12805079 Clinical Trial.
184 results