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Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis.
Hollinshead KER, Munford H, Eales KL, Bardella C, Li C, Escribano-Gonzalez C, Thakker A, Nonnenmacher Y, Kluckova K, Jeeves M, Murren R, Cuozzo F, Ye D, Laurenti G, Zhu W, Hiller K, Hodson DJ, Hua W, Tomlinson IP, Ludwig C, Mao Y, Tennant DA. Hollinshead KER, et al. Among authors: thakker a. Cell Rep. 2018 Mar 20;22(12):3107-3114. doi: 10.1016/j.celrep.2018.02.084. Cell Rep. 2018. PMID: 29562167 Free PMC article.
Metabolic tracing reveals novel adaptations to skeletal muscle cell energy production pathways in response to NAD + depletion.
Oakey LA, Fletcher RS, Elhassan YS, Cartwright DM, Doig CL, Garten A, Thakker A, Maddocks ODK, Zhang T, Tennant DA, Ludwig C, Lavery GG. Oakey LA, et al. Among authors: thakker a. Wellcome Open Res. 2019 Sep 17;3:147. doi: 10.12688/wellcomeopenres.14898.2. eCollection 2018. Wellcome Open Res. 2019. PMID: 30607371 Free PMC article.
A human pluripotent stem cell model for the analysis of metabolic dysfunction in hepatic steatosis.
Sinton MC, Meseguer-Ripolles J, Lucendo-Villarin B, Wernig-Zorc S, Thomson JP, Carter RN, Lyall MJ, Walker PD, Thakker A, Meehan RR, Lavery GG, Morton NM, Ludwig C, Tennant DA, Hay DC, Drake AJ. Sinton MC, et al. Among authors: thakker a. iScience. 2020 Dec 11;24(1):101931. doi: 10.1016/j.isci.2020.101931. eCollection 2021 Jan 22. iScience. 2020. PMID: 33409477 Free PMC article.
Loss of SDHB Promotes Dysregulated Iron Homeostasis, Oxidative Stress, and Sensitivity to Ascorbate.
Goncalves J, Moog S, Morin A, Gentric G, Müller S, Morrell AP, Kluckova K, Stewart TJ, Andoniadou CL, Lussey-Lepoutre C, Bénit P, Thakker A, Vettore L, Roberts J, Rodriguez R, Mechta-Grigoriou F, Gimenez-Roqueplo AP, Letouzé E, Tennant DA, Favier J. Goncalves J, et al. Among authors: thakker a. Cancer Res. 2021 Jul 1;81(13):3480-3494. doi: 10.1158/0008-5472.CAN-20-2936. Epub 2021 Jun 14. Cancer Res. 2021. PMID: 34127497 Free PMC article.
Prolyl-4-hydroxylase 3 maintains β cell glucose metabolism during fatty acid excess in mice.
Nasteska D, Cuozzo F, Viloria K, Johnson EM, Thakker A, Bany Bakar R, Westbrook RL, Barlow JP, Hoang M, Joseph JW, Lavery GG, Akerman I, Cantley J, Hodson L, Tennant DA, Hodson DJ. Nasteska D, et al. Among authors: thakker a. JCI Insight. 2021 Aug 23;6(16):e140288. doi: 10.1172/jci.insight.140288. JCI Insight. 2021. PMID: 34264866 Free PMC article.
Intracellular sodium elevation reprograms cardiac metabolism.
Aksentijević D, Karlstaedt A, Basalay MV, O'Brien BA, Sanchez-Tatay D, Eminaga S, Thakker A, Tennant DA, Fuller W, Eykyn TR, Taegtmeyer H, Shattock MJ. Aksentijević D, et al. Among authors: thakker a. Nat Commun. 2020 Aug 28;11(1):4337. doi: 10.1038/s41467-020-18160-x. Nat Commun. 2020. PMID: 32859897 Free PMC article.
51 results