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Page 1
mTOR inhibitors may benefit kidney transplant recipients with mitochondrial diseases.
Johnson SC, Martinez F, Bitto A, Gonzalez B, Tazaerslan C, Cohen C, Delaval L, Timsit J, Knebelmann B, Terzi F, Mahal T, Zhu Y, Morgan PG, Sedensky MM, Kaeberlein M, Legendre C, Suh Y, Canaud G. Johnson SC, et al. Kidney Int. 2019 Feb;95(2):455-466. doi: 10.1016/j.kint.2018.08.038. Epub 2018 Nov 22. Kidney Int. 2019. PMID: 30471880 Free PMC article.
Sir2 deletion prevents lifespan extension in 32 long-lived mutants.
Delaney JR, Sutphin GL, Dulken B, Sim S, Kim JR, Robison B, Schleit J, Murakami CJ, Carr D, An EH, Choi E, Chou A, Fletcher M, Jelic M, Liu B, Lockshon D, Moller RM, Pak DN, Peng Q, Peng ZJ, Pham KM, Sage M, Solanky A, Steffen KK, Tsuchiya M, Tsuchiyama S, Johnson S, Raabe C, Suh Y, Zhou Z, Liu X, Kennedy BK, Kaeberlein M. Delaney JR, et al. Aging Cell. 2011 Dec;10(6):1089-91. doi: 10.1111/j.1474-9726.2011.00742.x. Epub 2011 Oct 3. Aging Cell. 2011. PMID: 21902802 Free PMC article.
Preserving youth: does rapamycin deliver?
Johnson SC, Martin GM, Rabinovitch PS, Kaeberlein M. Johnson SC, et al. Sci Transl Med. 2013 Nov 13;5(211):211fs40. doi: 10.1126/scitranslmed.3007316. Sci Transl Med. 2013. PMID: 24225941 Free PMC article.
mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome.
Johnson SC, Yanos ME, Kayser EB, Quintana A, Sangesland M, Castanza A, Uhde L, Hui J, Wall VZ, Gagnidze A, Oh K, Wasko BM, Ramos FJ, Palmiter RD, Rabinovitch PS, Morgan PG, Sedensky MM, Kaeberlein M. Johnson SC, et al. Science. 2013 Dec 20;342(6165):1524-8. doi: 10.1126/science.1244360. Epub 2013 Nov 14. Science. 2013. PMID: 24231806 Free PMC article.
Modulating mTOR in aging and health.
Johnson SC, Sangesland M, Kaeberlein M, Rabinovitch PS. Johnson SC, et al. Interdiscip Top Gerontol. 2015;40:107-27. doi: 10.1159/000364974. Epub 2014 Oct 13. Interdiscip Top Gerontol. 2015. PMID: 25341517 Free article. Review.
Dose-dependent effects of mTOR inhibition on weight and mitochondrial disease in mice.
Johnson SC, Yanos ME, Bitto A, Castanza A, Gagnidze A, Gonzalez B, Gupta K, Hui J, Jarvie C, Johnson BM, Letexier N, McCanta L, Sangesland M, Tamis O, Uhde L, Van Den Ende A, Rabinovitch PS, Suh Y, Kaeberlein M. Johnson SC, et al. Among authors: johnson bm. Front Genet. 2015 Jul 22;6:247. doi: 10.3389/fgene.2015.00247. eCollection 2015. Front Genet. 2015. PMID: 26257774 Free PMC article.
A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging.
McCormick MA, Delaney JR, Tsuchiya M, Tsuchiyama S, Shemorry A, Sim S, Chou AC, Ahmed U, Carr D, Murakami CJ, Schleit J, Sutphin GL, Wasko BM, Bennett CF, Wang AM, Olsen B, Beyer RP, Bammler TK, Prunkard D, Johnson SC, Pennypacker JK, An E, Anies A, Castanza AS, Choi E, Dang N, Enerio S, Fletcher M, Fox L, Goswami S, Higgins SA, Holmberg MA, Hu D, Hui J, Jelic M, Jeong KS, Johnston E, Kerr EO, Kim J, Kim D, Kirkland K, Klum S, Kotireddy S, Liao E, Lim M, Lin MS, Lo WC, Lockshon D, Miller HA, Moller RM, Muller B, Oakes J, Pak DN, Peng ZJ, Pham KM, Pollard TG, Pradeep P, Pruett D, Rai D, Robison B, Rodriguez AA, Ros B, Sage M, Singh MK, Smith ED, Snead K, Solanky A, Spector BL, Steffen KK, Tchao BN, Ting MK, Vander Wende H, Wang D, Welton KL, Westman EA, Brem RB, Liu XG, Suh Y, Zhou Z, Kaeberlein M, Kennedy BK. McCormick MA, et al. Among authors: johnson sc. Cell Metab. 2015 Nov 3;22(5):895-906. doi: 10.1016/j.cmet.2015.09.008. Epub 2015 Oct 8. Cell Metab. 2015. PMID: 26456335 Free PMC article.
931 results