Sim L - Search Results

1

A Bacterial Expression Platform for Production of Therapeutic Proteins Containing Human-like O-Linked Glycans.

Du T, Buenbrazo N, Kell L, Rahmani S, Sim L, Withers SG, DeFrees S, Wakarchuk W. Du T, et al. Among authors: sim l. Cell Chem Biol. 2019 Feb 21;26(2):203-212.e5. doi: 10.1016/j.chembiol.2018.10.017. Epub 2018 Nov 29. Cell Chem Biol. 2019. PMID: 30503285 Free article.

2

Characterization of a thermostable endoglucanase from Cellulomonas fimi ATCC484.

Saxena H, Hsu B, de Asis M, Zierke M, Sim L, Withers SG, Wakarchuk W. Saxena H, et al. Among authors: sim l. Biochem Cell Biol. 2018 Feb;96(1):68-76. doi: 10.1139/bcb-2017-0150. Epub 2017 Oct 5. Biochem Cell Biol. 2018. PMID: 28982013

3

Directed evolution of bacterial polysialyltransferases.

Janesch B, Baumann L, Mark A, Thompson N, Rahmani S, Sim L, Withers SG, Wakarchuk WW. Janesch B, et al. Among authors: sim l. Glycobiology. 2019 Jul 1;29(7):588-598. doi: 10.1093/glycob/cwz021. Glycobiology. 2019. PMID: 30976781

4

Comparison of α2,6-sialyltransferases for sialylation of therapeutic proteins.

Janesch B, Saxena H, Sim L, Wakarchuk WW. Janesch B, et al. Among authors: sim l. Glycobiology. 2019 Sep 20;29(10):735-747. doi: 10.1093/glycob/cwz050. Glycobiology. 2019. PMID: 31281932

5

Discovery and Development of Promiscuous O-Glycan Hydrolases for Removal of Intact Sialyl T-Antigen.

Wardman JF, Rahfeld P, Liu F, Morgan-Lang C, Sim L, Hallam SJ, Withers SG. Wardman JF, et al. Among authors: sim l. ACS Chem Biol. 2021 Oct 15;16(10):2004-2015. doi: 10.1021/acschembio.1c00316. Epub 2021 Jul 26. ACS Chem Biol. 2021. PMID: 34309358

6

Mammalian sialyltransferases allow efficient Escherichia coli-based production of mucin-type O-glycoproteins but can also transfer Kdo.

Sim L, Thompson N, Geissner A, Withers SG, Wakarchuk WW. Sim L, et al. Glycobiology. 2022 Apr 21;32(5):429-440. doi: 10.1093/glycob/cwab130. Glycobiology. 2022. PMID: 34939113

7

X-ray crystallographic structure of a bacterial polysialyltransferase provides insight into the biosynthesis of capsular polysialic acid.

Lizak C, Worrall LJ, Baumann L, Pfleiderer MM, Volkers G, Sun T, Sim L, Wakarchuk W, Withers SG, Strynadka NCJ. Lizak C, et al. Among authors: sim l. Sci Rep. 2017 Jul 19;7(1):5842. doi: 10.1038/s41598-017-05627-z. Sci Rep. 2017. PMID: 28724897 Free PMC article.

8

7-Fluorosialyl Glycosides Are Hydrolysis Resistant but Readily Assembled by Sialyltransferases Providing Easy Access to More Metabolically Stable Glycoproteins.

Geissner A, Baumann L, Morley TJ, Wong AKO, Sim L, Rich JR, So PPL, Dullaghan EM, Lessard E, Iqbal U, Moreno M, Wakarchuk WW, Withers SG. Geissner A, et al. Among authors: sim l. ACS Cent Sci. 2021 Feb 24;7(2):345-354. doi: 10.1021/acscentsci.0c01589. Epub 2021 Jan 19. ACS Cent Sci. 2021. PMID: 33655072 Free PMC article.

9

An enzymatic pathway in the human gut microbiome that converts A to universal O type blood.

Rahfeld P, Sim L, Moon H, Constantinescu I, Morgan-Lang C, Hallam SJ, Kizhakkedathu JN, Withers SG. Rahfeld P, et al. Among authors: sim l. Nat Microbiol. 2019 Sep;4(9):1475-1485. doi: 10.1038/s41564-019-0469-7. Epub 2019 Jun 10. Nat Microbiol. 2019. PMID: 31182795

10

Prevention of vascular-allograft rejection by protecting the endothelial glycocalyx with immunosuppressive polymers.

Siren EMJ, Luo HD, Tam F, Montgomery A, Enns W, Moon H, Sim L, Rey K, Guan Q, Wang JJ, Wardell CM, Monajemi M, Mojibian M, Levings MK, Zhang ZJ, Du C, Withers SG, Choy JC, Kizhakkedathu JN. Siren EMJ, et al. Among authors: sim l. Nat Biomed Eng. 2021 Oct;5(10):1202-1216. doi: 10.1038/s41551-021-00777-y. Epub 2021 Aug 9. Nat Biomed Eng. 2021. PMID: 34373602

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