Darke PL - Search Results

1

Chemical synthesis and enzymatic activity of a 99-residue peptide with a sequence proposed for the human immunodeficiency virus protease.

Nutt RF, Brady SF, Darke PL, Ciccarone TM, Colton CD, Nutt EM, Rodkey JA, Bennett CD, Waxman LH, Sigal IS, et al. Nutt RF, et al. Among authors: darke pl. Proc Natl Acad Sci U S A. 1988 Oct;85(19):7129-33. doi: 10.1073/pnas.85.19.7129. Proc Natl Acad Sci U S A. 1988. PMID: 3050988 Free PMC article.

2

Human immunodeficiency virus protease. Bacterial expression and characterization of the purified aspartic protease.

Darke PL, Leu CT, Davis LJ, Heimbach JC, Diehl RE, Hill WS, Dixon RA, Sigal IS. Darke PL, et al. J Biol Chem. 1989 Feb 5;264(4):2307-12. J Biol Chem. 1989. PMID: 2644259 Free article.

3

Affinity purification of the HIV-1 protease.

Heimbach JC, Garsky VM, Michelson SR, Dixon RA, Sigal IS, Darke PL. Heimbach JC, et al. Among authors: darke pl. Biochem Biophys Res Commun. 1989 Nov 15;164(3):955-60. doi: 10.1016/0006-291x(89)91762-2. Biochem Biophys Res Commun. 1989. PMID: 2686642

4

HIV-1 protease specificity of peptide cleavage is sufficient for processing of gag and pol polyproteins.

Darke PL, Nutt RF, Brady SF, Garsky VM, Ciccarone TM, Leu CT, Lumma PK, Freidinger RM, Veber DF, Sigal IS. Darke PL, et al. Biochem Biophys Res Commun. 1988 Oct 14;156(1):297-303. doi: 10.1016/s0006-291x(88)80839-8. Biochem Biophys Res Commun. 1988. PMID: 3052448

5

Design and synthesis of HIV protease inhibitors. Variations of the carboxy terminus of the HIV protease inhibitor L-682,679.

deSolms SJ, Giuliani EA, Guare JP, Vacca JP, Sanders WM, Graham SL, Wiggins JM, Darke PL, Sigal IS, Zugay JA, et al. deSolms SJ, et al. Among authors: darke pl. J Med Chem. 1991 Sep;34(9):2852-7. doi: 10.1021/jm00113a025. J Med Chem. 1991. PMID: 1910089

6

Crystallization of the aspartylprotease from the human immunodeficiency virus, HIV-1.

McKeever BM, Navia MA, Fitzgerald PM, Springer JP, Leu CT, Heimbach JC, Herbert WK, Sigal IS, Darke PL. McKeever BM, et al. Among authors: darke pl. J Biol Chem. 1989 Feb 5;264(4):1919-21. J Biol Chem. 1989. PMID: 2644246 Free article.

7

Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1.

Navia MA, Fitzgerald PM, McKeever BM, Leu CT, Heimbach JC, Herber WK, Sigal IS, Darke PL, Springer JP. Navia MA, et al. Among authors: darke pl. Nature. 1989 Feb 16;337(6208):615-20. doi: 10.1038/337615a0. Nature. 1989. PMID: 2645523

8

Active human cytomegalovirus protease is a dimer.

Darke PL, Cole JL, Waxman L, Hall DL, Sardana MK, Kuo LC. Darke PL, et al. J Biol Chem. 1996 Mar 29;271(13):7445-9. doi: 10.1074/jbc.271.13.7445. J Biol Chem. 1996. PMID: 8631772 Free article.

9

The herpesvirus proteases as targets for antiviral chemotherapy.

Waxman L, Darke PL. Waxman L, et al. Among authors: darke pl. Antivir Chem Chemother. 2000 Jan;11(1):1-22. doi: 10.1177/095632020001100101. Antivir Chem Chemother. 2000. PMID: 10693650 Free article. Review.

10

Host cell factor requirement for hepatitis C virus enzyme maturation.

Waxman L, Whitney M, Pollok BA, Kuo LC, Darke PL. Waxman L, et al. Among authors: darke pl. Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13931-5. doi: 10.1073/pnas.241510898. Epub 2001 Nov 13. Proc Natl Acad Sci U S A. 2001. PMID: 11707594 Free PMC article.

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