de Frutos O - Search Results

1

Metallaphotoredox-Catalyzed Cross-Electrophile C_sp³-C_sp³ Coupling of Aliphatic Bromides.

Smith RT, Zhang X, Rincón JA, Agejas J, Mateos C, Barberis M, García-Cerrada S, de Frutos O, MacMillan DWC. Smith RT, et al. Among authors: de frutos o. J Am Chem Soc. 2018 Dec 19;140(50):17433-17438. doi: 10.1021/jacs.8b12025. Epub 2018 Dec 10. J Am Chem Soc. 2018. PMID: 30516995 Free PMC article.

2

A scalable procedure for light-induced benzylic brominations in continuous flow.

Cantillo D, de Frutos O, Rincon JA, Mateos C, Kappe CO. Cantillo D, et al. Among authors: de frutos o. J Org Chem. 2014 Jan 3;79(1):223-9. doi: 10.1021/jo402409k. Epub 2013 Nov 27. J Org Chem. 2014. PMID: 24261546

3

Continuous flow α-trifluoromethylation of ketones by metal-free visible light photoredox catalysis.

Cantillo D, de Frutos O, Rincón JA, Mateos C, Kappe CO. Cantillo D, et al. Among authors: de frutos o. Org Lett. 2014 Feb 7;16(3):896-9. doi: 10.1021/ol403650y. Epub 2014 Jan 16. Org Lett. 2014. PMID: 24432711

4

Discovery of a potent, dual serotonin and norepinephrine reuptake inhibitor.

Dreyfus N, Myers JK, Badescu VO, de Frutos O, de la Puente ML, Ding C, Filla SA, Fynboe K, Gernert DL, Heinz BA, Hemrick-Luecke SK, Johnson KW, Johnson MP, López P, Love PL, Martin LJ, Masquelin T, McCoy MJ, Mendiola J, Morrow D, Muhlhauser M, Pascual G, Perun TJ, Pfeifer LA, Phebus LA, Richards SJ, Rincón JA, Seest EP, Shah J, Shaojuan J, Simmons RM, Stephenson GA, Tromiczak EG, Thompson LK, Walter MW, Weber WW, Zarrinmayeh H, Thomas CE, Joshi E, Iyengar S, Johansson AM. Dreyfus N, et al. Among authors: de la puente ml, de frutos o. ACS Med Chem Lett. 2013 May 7;4(6):560-4. doi: 10.1021/ml400049p. eCollection 2013 Jun 13. ACS Med Chem Lett. 2013. PMID: 24900709 Free PMC article.

5

A continuous-flow protocol for light-induced benzylic fluorinations.

Cantillo D, de Frutos O, Rincón JA, Mateos C, Kappe CO. Cantillo D, et al. Among authors: de frutos o. J Org Chem. 2014 Sep 5;79(17):8486-90. doi: 10.1021/jo5016757. Epub 2014 Aug 26. J Org Chem. 2014. PMID: 25144336

6

Light-Induced C-H Arylation of (Hetero)arenes by In Situ Generated Diazo Anhydrides.

Cantillo D, Mateos C, Rincon JA, de Frutos O, Kappe CO. Cantillo D, et al. Among authors: de frutos o. Chemistry. 2015 Sep 7;21(37):12894-8. doi: 10.1002/chem.201502357. Epub 2015 Aug 3. Chemistry. 2015. PMID: 26239967

7

Electrochemical Deprotection of para-Methoxybenzyl Ethers in a Flow Electrolysis Cell.

Green RA, Jolley KE, Al-Hadedi AAM, Pletcher D, Harrowven DC, De Frutos O, Mateos C, Klauber DJ, Rincón JA, Brown RCD. Green RA, et al. Among authors: de frutos o. Org Lett. 2017 Apr 21;19(8):2050-2053. doi: 10.1021/acs.orglett.7b00641. Epub 2017 Apr 4. Org Lett. 2017. PMID: 28375019

8

Discovery of chiral dihydropyridopyrimidinones as potent, selective and orally bioavailable inhibitors of AKT.

Parthasarathy S, Henry K, Pei H, Clayton J, Rempala M, Johns D, De Frutos O, Garcia P, Mateos C, Pleite S, Wang Y, Stout S, Condon B, Ashok S, Lu Z, Ehlhardt W, Raub T, Lai M, Geeganage S, Burkholder TP. Parthasarathy S, et al. Among authors: de frutos o. Bioorg Med Chem Lett. 2018 Jun 1;28(10):1887-1891. doi: 10.1016/j.bmcl.2018.03.092. Epub 2018 Apr 2. Bioorg Med Chem Lett. 2018. PMID: 29655979

9

Photochemical benzylic bromination in continuous flow using BrCCl₃ and its application to telescoped p-methoxybenzyl protection.

Otake Y, Williams JD, Rincón JA, de Frutos O, Mateos C, Kappe CO. Otake Y, et al. Among authors: de frutos o. Org Biomol Chem. 2019 Feb 6;17(6):1384-1388. doi: 10.1039/c9ob00044e. Org Biomol Chem. 2019. PMID: 30676602

10

Rapid Optimization of Photoredox Reactions for Continuous-Flow Systems Using Microscale Batch Technology.

González-Esguevillas M, Fernández DF, Rincón JA, Barberis M, de Frutos O, Mateos C, García-Cerrada S, Agejas J, MacMillan DWC. González-Esguevillas M, et al. Among authors: de frutos o. ACS Cent Sci. 2021 Jul 28;7(7):1126-1134. doi: 10.1021/acscentsci.1c00303. Epub 2021 Jun 8. ACS Cent Sci. 2021. PMID: 34345665 Free PMC article.

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