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Low induction of proinflammatory cytokines parallels evolutionary success of modern strains within the Mycobacterium tuberculosis Beijing genotype.
van Laarhoven A, Mandemakers JJ, Kleinnijenhuis J, Enaimi M, Lachmandas E, Joosten LA, Ottenhoff TH, Netea MG, van Soolingen D, van Crevel R. van Laarhoven A, et al. Among authors: lachmandas e. Infect Immun. 2013 Oct;81(10):3750-6. doi: 10.1128/IAI.00282-13. Epub 2013 Jul 29. Infect Immun. 2013. PMID: 23897611 Free PMC article.
Rewiring cellular metabolism via the AKT/mTOR pathway contributes to host defence against Mycobacterium tuberculosis in human and murine cells.
Lachmandas E, Beigier-Bompadre M, Cheng SC, Kumar V, van Laarhoven A, Wang X, Ammerdorffer A, Boutens L, de Jong D, Kanneganti TD, Gresnigt MS, Ottenhoff TH, Joosten LA, Stienstra R, Wijmenga C, Kaufmann SH, van Crevel R, Netea MG. Lachmandas E, et al. Eur J Immunol. 2016 Nov;46(11):2574-2586. doi: 10.1002/eji.201546259. Epub 2016 Sep 27. Eur J Immunol. 2016. PMID: 27624090 Free PMC article.
Role of glutathione metabolism in host defense against Borrelia burgdorferi infection.
Kerstholt M, Vrijmoeth H, Lachmandas E, Oosting M, Lupse M, Flonta M, Dinarello CA, Netea MG, Joosten LAB. Kerstholt M, et al. Among authors: lachmandas e. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2320-E2328. doi: 10.1073/pnas.1720833115. Epub 2018 Feb 14. Proc Natl Acad Sci U S A. 2018. PMID: 29444855 Free PMC article.
Tissue Metabolic Changes Drive Cytokine Responses to Mycobacterium tuberculosis.
Lachmandas E, Rios-Miguel AB, Koeken VACM, van der Pasch E, Kumar V, Matzaraki V, Li Y, Oosting M, Joosten LAB, Notebaart RA, Noursadeghi M, Netea MG, van Crevel R, Pollara G. Lachmandas E, et al. J Infect Dis. 2018 Jun 5;218(1):165-170. doi: 10.1093/infdis/jiy173. J Infect Dis. 2018. PMID: 29618104 Free PMC article.
Metformin Alters Human Host Responses to Mycobacterium tuberculosis in Healthy Subjects.
Lachmandas E, Eckold C, Böhme J, Koeken VACM, Marzuki MB, Blok B, Arts RJW, Chen J, Teng KWW, Ratter J, Smolders EJ, Van den Heuvel C, Stienstra R, Dockrell HM, Newell E, Netea MG, Singhal A, Cliff JM, Van Crevel R. Lachmandas E, et al. J Infect Dis. 2019 Jun 5;220(1):139-150. doi: 10.1093/infdis/jiz064. J Infect Dis. 2019. PMID: 30753544 Free PMC article.
Rewiring of glucose metabolism defines trained immunity induced by oxidized low-density lipoprotein.
Keating ST, Groh L, Thiem K, Bekkering S, Li Y, Matzaraki V, van der Heijden CDCC, van Puffelen JH, Lachmandas E, Jansen T, Oosting M, de Bree LCJ, Koeken VACM, Moorlag SJCFM, Mourits VP, van Diepen J, Strienstra R, Novakovic B, Stunnenberg HG, van Crevel R, Joosten LAB, Netea MG, Riksen NP. Keating ST, et al. Among authors: lachmandas e. J Mol Med (Berl). 2020 Jun;98(6):819-831. doi: 10.1007/s00109-020-01915-w. Epub 2020 Apr 30. J Mol Med (Berl). 2020. PMID: 32350546 Free PMC article.
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