Takakusa H - Search Results

1

Pharmacokinetics, Metabolism, and Excretion of [¹⁴C]Esaxerenone, a Novel Mineralocorticoid Receptor Blocker in Humans.

Yamada M, Mendell J, Takakusa H, Shimizu T, Ando O. Yamada M, et al. Among authors: takakusa h. Drug Metab Dispos. 2019 Mar;47(3):340-349. doi: 10.1124/dmd.118.084897. Epub 2018 Dec 12. Drug Metab Dispos. 2019. PMID: 30541878 Clinical Trial.

2

Covalent binding and tissue distribution/retention assessment of drugs associated with idiosyncratic drug toxicity.

Takakusa H, Masumoto H, Yukinaga H, Makino C, Nakayama S, Okazaki O, Sudo K. Takakusa H, et al. Drug Metab Dispos. 2008 Sep;36(9):1770-9. doi: 10.1124/dmd.108.021725. Epub 2008 May 28. Drug Metab Dispos. 2008. PMID: 18508880

3

A zone classification system for risk assessment of idiosyncratic drug toxicity using daily dose and covalent binding.

Nakayama S, Atsumi R, Takakusa H, Kobayashi Y, Kurihara A, Nagai Y, Nakai D, Okazaki O. Nakayama S, et al. Among authors: takakusa h. Drug Metab Dispos. 2009 Sep;37(9):1970-7. doi: 10.1124/dmd.109.027797. Epub 2009 Jun 1. Drug Metab Dispos. 2009. PMID: 19487250

4

Pharmacokinetics and disposition of CS-8958, a long-acting prodrug of the novel neuraminidase inhibitor laninamivir in rats.

Koyama K, Takahashi M, Nakai N, Takakusa H, Murai T, Hoshi M, Yamamura N, Kobayashi N, Okazaki O. Koyama K, et al. Among authors: takakusa h. Xenobiotica. 2010 Mar;40(3):207-16. doi: 10.3109/00498250903447691. Xenobiotica. 2010. PMID: 20146556

5

Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites.

Nakayama S, Takakusa H, Watanabe A, Miyaji Y, Suzuki W, Sugiyama D, Shiosakai K, Honda K, Okudaira N, Izumi T, Okazaki O. Nakayama S, et al. Among authors: takakusa h. Drug Metab Dispos. 2011 Jul;39(7):1247-54. doi: 10.1124/dmd.111.039180. Epub 2011 Apr 5. Drug Metab Dispos. 2011. PMID: 21467212

6

Tissue distribution and identification of radioactivity components at elimination phase after oral administration of [¹⁴C]CS-1036, an α-amylase inhibitor, to rats.

Honda T, Takakusa H, Murai T, Izumi T. Honda T, et al. Among authors: takakusa h. Drug Metab Dispos. 2013 May;41(5):1125-33. doi: 10.1124/dmd.112.050617. Epub 2013 Mar 1. Drug Metab Dispos. 2013. PMID: 23454829

7

Metabolism and disposition of [(14)C]tivantinib after oral administration to humans, dogs and rats.

Murai T, Takakusa H, Nakai D, Kamiyama E, Taira T, Kimura T, Jimbo T, Bathala M, Pickersgill F, Zahir H, Tokui T, Savage RE, Ashwell MA, Izumi T. Murai T, et al. Among authors: takakusa h. Xenobiotica. 2014 Nov;44(11):996-1008. doi: 10.3109/00498254.2014.926572. Epub 2014 Jun 9. Xenobiotica. 2014. PMID: 24911380

8

Analysis of Mechanism-Based Inhibition of CYP 3A4 by a Series of Fluoroquinolone Antibacterial Agents.

Watanabe A, Takakusa H, Kimura T, Inoue S, Kusuhara H, Ando O. Watanabe A, et al. Among authors: takakusa h. Drug Metab Dispos. 2016 Oct;44(10):1608-16. doi: 10.1124/dmd.116.071654. Epub 2016 Jul 28. Drug Metab Dispos. 2016. PMID: 27469000

9

Pharmacokinetics, distribution, and disposition of esaxerenone, a novel, highly potent and selective non-steroidal mineralocorticoid receptor antagonist, in rats and monkeys.

Yamada M, Takei M, Suzuki E, Takakusa H, Kotsuma M, Washio T, Murayama N, Inoue SI, Izumi T. Yamada M, et al. Among authors: takakusa h. Xenobiotica. 2017 Dec;47(12):1090-1103. doi: 10.1080/00498254.2016.1263766. Epub 2016 Dec 12. Xenobiotica. 2017. PMID: 27866463

10

Difference in Mechanism-Based Inhibition of Cytochrome P450 3A4 and 3A5 by a Series of Fluoroquinolone Antibacterial Agents.

Watanabe A, Takakusa H, Kimura T, Inoue SI, Kusuhara H, Ando O. Watanabe A, et al. Among authors: takakusa h. Drug Metab Dispos. 2017 Mar;45(3):336-341. doi: 10.1124/dmd.116.073783. Epub 2016 Dec 14. Drug Metab Dispos. 2017. PMID: 27974381

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