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Human Immunodeficiency Virus Type 1 RNA Detected in the Central Nervous System (CNS) After Years of Suppressive Antiretroviral Therapy Can Originate from a Replicating CNS Reservoir or Clonally Expanded Cells.
Joseph SB, Kincer LP, Bowman NM, Evans C, Vinikoor MJ, Lippincott CK, Gisslén M, Spudich S, Menezes P, Robertson K, Archin N, Kashuba A, Eron JJ, Price RW, Swanstrom R. Joseph SB, et al. Among authors: archin n. Clin Infect Dis. 2019 Sep 27;69(8):1345-1352. doi: 10.1093/cid/ciy1066. Clin Infect Dis. 2019. PMID: 30561541 Free PMC article.
A targeted CRISPR screen identifies ETS1 as a regulator of HIV latency.
Ashokkumar M, Hafer TL, Felton A, Archin NM, Margolis DM, Emerman M, Browne EP. Ashokkumar M, et al. Among authors: archin nm. bioRxiv [Preprint]. 2024 Aug 3:2024.08.03.606477. doi: 10.1101/2024.08.03.606477. bioRxiv. 2024. PMID: 39211204 Free PMC article. Preprint.
Machine learning approaches identify immunologic signatures of total and intact HIV DNA during long-term antiretroviral therapy.
Semenova L, Wang Y, Falcinelli S, Archin N, Cooper-Volkheimer AD, Margolis DM, Goonetilleke N, Murdoch DM, Rudin CD, Browne EP. Semenova L, et al. Among authors: archin n. bioRxiv [Preprint]. 2024 Jun 25:2023.11.16.567386. doi: 10.1101/2023.11.16.567386. bioRxiv. 2024. Update in: Elife. 2024 Sep 09;13:RP94899. doi: 10.7554/eLife.94899 PMID: 38014340 Free PMC article. Updated. Preprint.
Clonal sequences recovered from plasma from patients with residual HIV-1 viremia and on intensified antiretroviral therapy are identical to replicating viral RNAs recovered from circulating resting CD4+ T cells.
Anderson JA, Archin NM, Ince W, Parker D, Wiegand A, Coffin JM, Kuruc J, Eron J, Swanstrom R, Margolis DM. Anderson JA, et al. J Virol. 2011 May;85(10):5220-3. doi: 10.1128/JVI.00284-11. Epub 2011 Mar 2. J Virol. 2011. PMID: 21367910 Free PMC article.
Immediate antiviral therapy appears to restrict resting CD4+ cell HIV-1 infection without accelerating the decay of latent infection.
Archin NM, Vaidya NK, Kuruc JD, Liberty AL, Wiegand A, Kearney MF, Cohen MS, Coffin JM, Bosch RJ, Gay CL, Eron JJ, Margolis DM, Perelson AS. Archin NM, et al. Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9523-8. doi: 10.1073/pnas.1120248109. Epub 2012 May 29. Proc Natl Acad Sci U S A. 2012. PMID: 22645358 Free PMC article.
Emerging strategies to deplete the HIV reservoir.
Archin NM, Margolis DM. Archin NM, et al. Curr Opin Infect Dis. 2014 Feb;27(1):29-35. doi: 10.1097/QCO.0000000000000026. Curr Opin Infect Dis. 2014. PMID: 24296585 Free PMC article. Review.
An in-depth comparison of latent HIV-1 reactivation in multiple cell model systems and resting CD4+ T cells from aviremic patients.
Spina CA, Anderson J, Archin NM, Bosque A, Chan J, Famiglietti M, Greene WC, Kashuba A, Lewin SR, Margolis DM, Mau M, Ruelas D, Saleh S, Shirakawa K, Siliciano RF, Singhania A, Soto PC, Terry VH, Verdin E, Woelk C, Wooden S, Xing S, Planelles V. Spina CA, et al. PLoS Pathog. 2013;9(12):e1003834. doi: 10.1371/journal.ppat.1003834. Epub 2013 Dec 26. PLoS Pathog. 2013. PMID: 24385908 Free PMC article.
112 results