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Depletion of high-content CD14+ cells from apheresis products is critical for successful transduction and expansion of CAR T cells during large-scale cGMP manufacturing.
Wang X, Borquez-Ojeda O, Stefanski J, Du F, Qu J, Chaudhari J, Thummar K, Zhu M, Shen LB, Hall M, Gautam P, Wang Y, Sénéchal B, Sikder D, Adusumilli PS, Brentjens RJ, Curran K, Geyer MB, Mailankhody S, O'Cearbhaill R, Park JH, Sauter C, Slovin S, Smith EL, Rivière I. Wang X, et al. Among authors: shen lb. Mol Ther Methods Clin Dev. 2021 Jul 16;22:377-387. doi: 10.1016/j.omtm.2021.06.014. eCollection 2021 Sep 10. Mol Ther Methods Clin Dev. 2021. PMID: 34514029 Free PMC article.
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