Downward J - Search Results

1

Disruption of the Interaction of RAS with PI 3-Kinase Induces Regression of EGFR-Mutant-Driven Lung Cancer.

Murillo MM, Rana S, Spencer-Dene B, Nye E, Stamp G, Downward J. Murillo MM, et al. Among authors: downward j. Cell Rep. 2018 Dec 26;25(13):3545-3553.e2. doi: 10.1016/j.celrep.2018.12.003. Cell Rep. 2018. PMID: 30590030 Free PMC article.

2

The activation of phosphatidylinositol 3-kinase by Ras.

Kodaki T, Woscholski R, Hallberg B, Rodriguez-Viciana P, Downward J, Parker PJ. Kodaki T, et al. Among authors: downward j. Curr Biol. 1994 Sep 1;4(9):798-806. doi: 10.1016/s0960-9822(00)00177-9. Curr Biol. 1994. PMID: 7820549

3

Phosphatidylinositol-3-OH kinase as a direct target of Ras.

Rodriguez-Viciana P, Warne PH, Dhand R, Vanhaesebroeck B, Gout I, Fry MJ, Waterfield MD, Downward J. Rodriguez-Viciana P, et al. Among authors: downward j. Nature. 1994 Aug 18;370(6490):527-32. doi: 10.1038/370527a0. Nature. 1994. PMID: 8052307

4

Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation.

Rodriguez-Viciana P, Warne PH, Vanhaesebroeck B, Waterfield MD, Downward J. Rodriguez-Viciana P, et al. Among authors: downward j. EMBO J. 1996 May 15;15(10):2442-51. EMBO J. 1996. PMID: 8665852 Free PMC article.

5

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

Kauffmann-Zeh A, Rodriguez-Viciana P, Ulrich E, Gilbert C, Coffer P, Downward J, Evan G. Kauffmann-Zeh A, et al. Among authors: downward j. Nature. 1997 Feb 6;385(6616):544-8. doi: 10.1038/385544a0. Nature. 1997. PMID: 9020362

6

Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras.

Rodriguez-Viciana P, Warne PH, Khwaja A, Marte BM, Pappin D, Das P, Waterfield MD, Ridley A, Downward J. Rodriguez-Viciana P, et al. Among authors: downward j. Cell. 1997 May 2;89(3):457-67. doi: 10.1016/s0092-8674(00)80226-3. Cell. 1997. PMID: 9150145 Free article.

7

Ras signalling and apoptosis.

Downward J. Downward J. Curr Opin Genet Dev. 1998 Feb;8(1):49-54. doi: 10.1016/s0959-437x(98)80061-0. Curr Opin Genet Dev. 1998. PMID: 9529605 Review.

8

Role of receptor tyrosine kinases in G-protein-coupled receptor regulation of Ras: transactivation or parallel pathways?

Downward J. Downward J. Biochem J. 2003 Dec 15;376(Pt 3):e9-10. doi: 10.1042/BJ20031745. Biochem J. 2003. PMID: 14656216 Free PMC article.

9

PI 3-kinase, Akt and cell survival.

Downward J. Downward J. Semin Cell Dev Biol. 2004 Apr;15(2):177-82. doi: 10.1016/j.semcdb.2004.01.002. Semin Cell Dev Biol. 2004. PMID: 15209377 Review.

10

Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice.

Gupta S, Ramjaun AR, Haiko P, Wang Y, Warne PH, Nicke B, Nye E, Stamp G, Alitalo K, Downward J. Gupta S, et al. Among authors: downward j. Cell. 2007 Jun 1;129(5):957-68. doi: 10.1016/j.cell.2007.03.051. Cell. 2007. PMID: 17540175 Free article.

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