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Heterozygous Pkhd1C642* mice develop cystic liver disease and proximal tubule ectasia that mimics radiographic signs of medullary sponge kidney.
Shan D, Rezonzew G, Mullen S, Roye R, Zhou J, Chumley P, Revell DZ, Challa A, Kim H, Lockhart ME, Schoeb TR, Croyle MJ, Kesterson RA, Yoder BK, Guay-Woodford LM, Mrug M. Shan D, et al. Among authors: chumley p. Am J Physiol Renal Physiol. 2019 Mar 1;316(3):F463-F472. doi: 10.1152/ajprenal.00181.2018. Epub 2019 Jan 2. Am J Physiol Renal Physiol. 2019. PMID: 30600684 Free PMC article.
Truncating PKHD1 and PKD2 mutations alter energy metabolism.
Chumley P, Zhou J, Mrug S, Chacko B, Parant JM, Challa AK, Wilson LS, Berryhill TF, Barnes S, Kesterson RA, Bell PD, Darley-Usmar VM, Yoder BK, Mrug M. Chumley P, et al. Am J Physiol Renal Physiol. 2019 Mar 1;316(3):F414-F425. doi: 10.1152/ajprenal.00167.2018. Epub 2018 Dec 19. Am J Physiol Renal Physiol. 2019. PMID: 30566001 Free PMC article.
A kidney resident macrophage subset is a candidate biomarker for renal cystic disease in preclinical models.
Li Z, Zimmerman KA, Cherakara S, Chumley PH, Collawn JF, Wang J, Haycraft CJ, Song CJ, Chacana T, Andersen RS, Croyle MJ, Aloria EJ, Hombal RP, Thomas IN, Chweih H, Simanyi KL, George JF, Parant JM, Mrug M, Yoder BK. Li Z, et al. Among authors: chumley ph. Dis Model Mech. 2023 Jan 1;16(1):dmm049810. doi: 10.1242/dmm.049810. Epub 2023 Jan 16. Dis Model Mech. 2023. PMID: 36457161 Free PMC article.
Accuracy and processing time of kidney volume measurement methods in rodents polycystic kidney disease models: superiority of semiautomated kidney segmentation.
Doss MC, Mullen S, Roye R, Zhou J, Chumley P, Mrug E, Wallace DP, Qian F, Harris PC, Yoder BK, Kim H, Mrug M. Doss MC, et al. Among authors: chumley p. Am J Physiol Renal Physiol. 2023 Apr 1;324(4):F423-F430. doi: 10.1152/ajprenal.00295.2022. Epub 2023 Feb 16. Am J Physiol Renal Physiol. 2023. PMID: 36794756 Free PMC article.
40 results