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Human PAH is characterized by a pattern of lipid-related insulin resistance.
Hemnes AR, Luther JM, Rhodes CJ, Burgess JP, Carlson J, Fan R, Fessel JP, Fortune N, Gerszten RE, Halliday SJ, Hekmat R, Howard L, Newman JH, Niswender KD, Pugh ME, Robbins IM, Sheng Q, Shibao CA, Shyr Y, Sumner S, Talati M, Wharton J, Wilkins MR, Ye F, Yu C, West J, Brittain EL. Hemnes AR, et al. Among authors: howard l. JCI Insight. 2019 Jan 10;4(1):e123611. doi: 10.1172/jci.insight.123611. JCI Insight. 2019. PMID: 30626738 Free PMC article.
Emerging therapies for pulmonary arterial hypertension.
Ali O, Wharton J, Gibbs JS, Howard L, Wilkins MR. Ali O, et al. Among authors: howard l. Expert Opin Investig Drugs. 2007 Jun;16(6):803-18. doi: 10.1517/13543784.16.6.803. Expert Opin Investig Drugs. 2007. PMID: 17501693 Review.
Simvastatin as a treatment for pulmonary hypertension trial.
Wilkins MR, Ali O, Bradlow W, Wharton J, Taegtmeyer A, Rhodes CJ, Ghofrani HA, Howard L, Nihoyannopoulos P, Mohiaddin RH, Gibbs JS; Simvastatin Pulmonary Hypertension Trial (SiPHT) Study Group. Wilkins MR, et al. Among authors: howard l. Am J Respir Crit Care Med. 2010 May 15;181(10):1106-13. doi: 10.1164/rccm.2009111-699oc. Am J Respir Crit Care Med. 2010. PMID: 20460548 Free PMC article. Clinical Trial.
Safety of sapropterin dihydrochloride (6r-bh4) in patients with pulmonary hypertension.
Robbins IM, Hemnes AR, Gibbs JS, Christman BW, Howard L, Meehan S, Cabrita I, Gonzalez R, Oyler T, Zhao L, Du RH, Mendes LA, Wilkins MR. Robbins IM, et al. Among authors: howard l. Exp Lung Res. 2011 Feb;37(1):26-34. doi: 10.3109/01902148.2010.512972. Epub 2010 Nov 15. Exp Lung Res. 2011. PMID: 21077779 Free article. Clinical Trial.
Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients.
Michelakis ED, Gurtu V, Webster L, Barnes G, Watson G, Howard L, Cupitt J, Paterson I, Thompson RB, Chow K, O'Regan DP, Zhao L, Wharton J, Kiely DG, Kinnaird A, Boukouris AE, White C, Nagendran J, Freed DH, Wort SJ, Gibbs JSR, Wilkins MR. Michelakis ED, et al. Among authors: howard l. Sci Transl Med. 2017 Oct 25;9(413):eaao4583. doi: 10.1126/scitranslmed.aao4583. Sci Transl Med. 2017. PMID: 29070699 Free article. Clinical Trial.
Characterization of GDF2 Mutations and Levels of BMP9 and BMP10 in Pulmonary Arterial Hypertension.
Hodgson J, Swietlik EM, Salmon RM, Hadinnapola C, Nikolic I, Wharton J, Guo J, Liley J, Haimel M, Bleda M, Southgate L, Machado RD, Martin JM, Treacy CM, Yates K, Daugherty LC, Shamardina O, Whitehorn D, Holden S, Bogaard HJ, Church C, Coghlan G, Condliffe R, Corris PA, Danesino C, Eyries M, Gall H, Ghio S, Ghofrani HA, Gibbs JSR, Girerd B, Houweling AC, Howard L, Humbert M, Kiely DG, Kovacs G, Lawrie A, MacKenzie Ross RV, Moledina S, Montani D, Olschewski A, Olschewski H, Ouwehand WH, Peacock AJ, Pepke-Zaba J, Prokopenko I, Rhodes CJ, Scelsi L, Seeger W, Soubrier F, Suntharalingam J, Toshner MR, Trembath RC, Vonk Noordegraaf A, Wort SJ, Wilkins MR, Yu PB, Li W, Gräf S, Upton PD, Morrell NW. Hodgson J, et al. Among authors: howard l. Am J Respir Crit Care Med. 2020 Mar 1;201(5):575-585. doi: 10.1164/rccm.201906-1141OC. Am J Respir Crit Care Med. 2020. PMID: 31661308 Free PMC article.
Bayesian Inference Associates Rare KDR Variants with Specific Phenotypes in Pulmonary Arterial Hypertension.
Swietlik EM, Greene D, Zhu N, Megy K, Cogliano M, Rajaram S, Pandya D, Tilly T, Lutz KA, Welch CCL, Pauciulo MW, Southgate L, Martin JM, Treacy CM, Penkett CJ, Stephens JC, Bogaard HJ, Church C, Coghlan G, Coleman AW, Condliffe R, Eichstaedt CA, Eyries M, Gall H, Ghio S, Girerd B, Grünig E, Holden S, Howard L, Humbert M, Kiely DG, Kovacs G, Lordan J, Machado RD, Mackenzie Ross RV, McCabe C, Moledina S, Montani D, Olschewski H, Pepke-Zaba J, Price L, Rhodes CJ, Seeger W, Soubrier F, Suntharalingam J, Toshner MR, Vonk Noordegraaf A, Wharton J, Wild JM, Wort SJ, Lawrie A, Wilkins MR, Trembath RC, Shen Y, Chung WK, Swift AJ, Nichols WC, Morrell NW, Gräf S. Swietlik EM, et al. Among authors: howard l. Circ Genom Precis Med. 2020 Dec 15;14(1):e003155. doi: 10.1161/CIRCGEN.120.003155. Online ahead of print. Circ Genom Precis Med. 2020. PMID: 33320693 Free PMC article.
1,772 results