Dowson CG - Search Results

1

Structural studies suggest aggregation as one of the modes of action for teixobactin.

Öster C, Walkowiak GP, Hughes DE, Spoering AL, Peoples AJ, Catherwood AC, Tod JA, Lloyd AJ, Herrmann T, Lewis K, Dowson CG, Lewandowski JR. Öster C, et al. Among authors: dowson cg. Chem Sci. 2018 Sep 20;9(47):8850-8859. doi: 10.1039/c8sc03655a. eCollection 2018 Dec 21. Chem Sci. 2018. PMID: 30627403 Free PMC article.

2

Expression, purification, crystallization and preliminary characterization of uridine 5'-diphospho-N-acetylmuramoyl L-alanyl-D-glutamate:lysine ligase (MurE) from Streptococcus pneumoniae 110K/70.

Blewett AM, Lloyd AJ, Echalier A, Fülöp V, Dowson CG, Bugg TD, Roper DI. Blewett AM, et al. Among authors: dowson cg. Acta Crystallogr D Biol Crystallogr. 2004 Feb;60(Pt 2):359-61. doi: 10.1107/S0907444903027720. Epub 2004 Jan 23. Acta Crystallogr D Biol Crystallogr. 2004. PMID: 14747725

3

IFN-gamma enhances production of nitric oxide from macrophages via a mechanism that depends on nucleotide oligomerization domain-2.

Tötemeyer S, Sheppard M, Lloyd A, Roper D, Dowson C, Underhill D, Murray P, Maskell D, Bryant C. Tötemeyer S, et al. J Immunol. 2006 Apr 15;176(8):4804-10. doi: 10.4049/jimmunol.176.8.4804. J Immunol. 2006. PMID: 16585574

4

Fluorescent reagents for in vitro studies of lipid-linked steps of bacterial peptidoglycan biosynthesis: derivatives of UDPMurNAc-pentapeptide containing d-cysteine at position 4 or 5.

Schouten JA, Bagga S, Lloyd AJ, de Pascale G, Dowson CG, Roper DI, Bugg TD. Schouten JA, et al. Among authors: dowson cg. Mol Biosyst. 2006 Oct;2(10):484-91. doi: 10.1039/b607908c. Epub 2006 Sep 7. Mol Biosyst. 2006. PMID: 17216029

5

Adenosine phosphonate inhibitors of lipid II: alanyl tRNA ligase MurM from Streptococcus pneumoniae.

Cressina E, Lloyd AJ, De Pascale G, Roper DI, Dowson CG, Bugg TD. Cressina E, et al. Among authors: dowson cg. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4654-6. doi: 10.1016/j.bmcl.2007.05.071. Epub 2007 May 25. Bioorg Med Chem Lett. 2007. PMID: 17548193

6

Characterization of tRNA-dependent peptide bond formation by MurM in the synthesis of Streptococcus pneumoniae peptidoglycan.

Lloyd AJ, Gilbey AM, Blewett AM, De Pascale G, El Zoeiby A, Levesque RC, Catherwood AC, Tomasz A, Bugg TD, Roper DI, Dowson CG. Lloyd AJ, et al. Among authors: dowson cg. J Biol Chem. 2008 Mar 7;283(10):6402-17. doi: 10.1074/jbc.M708105200. Epub 2007 Dec 12. J Biol Chem. 2008. PMID: 18077448 Free article.

7

Kinetic characterization of lipid II-Ala:alanyl-tRNA ligase (MurN) from Streptococcus pneumoniae using semisynthetic aminoacyl-lipid II substrates.

De Pascale G, Lloyd AJ, Schouten JA, Gilbey AM, Roper DI, Dowson CG, Bugg TD. De Pascale G, et al. Among authors: dowson cg. J Biol Chem. 2008 Dec 12;283(50):34571-9. doi: 10.1074/jbc.M805807200. Epub 2008 Oct 8. J Biol Chem. 2008. PMID: 18842590 Free PMC article.

8

Inhibition of tRNA-dependent ligase MurM from Streptococcus pneumoniae by phosphonate and sulfonamide inhibitors.

Cressina E, Lloyd AJ, De Pascale G, James Mok B, Caddick S, Roper DI, Dowson CG, Bugg TD. Cressina E, et al. Among authors: dowson cg. Bioorg Med Chem. 2009 May 1;17(9):3443-55. doi: 10.1016/j.bmc.2009.03.028. Epub 2009 Mar 21. Bioorg Med Chem. 2009. PMID: 19356937

9

Adenosine tetraphosphoadenosine drives a continuous ATP-release assay for aminoacyl-tRNA synthetases and other adenylate-forming enzymes.

Lloyd AJ, Potter NJ, Fishwick CW, Roper DI, Dowson CG. Lloyd AJ, et al. Among authors: dowson cg. ACS Chem Biol. 2013 Oct 18;8(10):2157-63. doi: 10.1021/cb400248f. Epub 2013 Aug 13. ACS Chem Biol. 2013. PMID: 23898887 Free article.

10

Specificity determinants for lysine incorporation in Staphylococcus aureus peptidoglycan as revealed by the structure of a MurE enzyme ternary complex.

Ruane KM, Lloyd AJ, Fülöp V, Dowson CG, Barreteau H, Boniface A, Dementin S, Blanot D, Mengin-Lecreulx D, Gobec S, Dessen A, Roper DI. Ruane KM, et al. Among authors: dowson cg. J Biol Chem. 2013 Nov 15;288(46):33439-48. doi: 10.1074/jbc.M113.508135. Epub 2013 Sep 24. J Biol Chem. 2013. PMID: 24064214 Free PMC article.

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