Fu W - Search Results

1

Discovery of Novel Androgen Receptor Ligands by Structure-based Virtual Screening and Bioassays.

Zhou W, Duan M, Fu W, Pang J, Tang Q, Sun H, Xu L, Chang S, Li D, Hou T. Zhou W, et al. Among authors: fu w. Genomics Proteomics Bioinformatics. 2018 Dec;16(6):416-427. doi: 10.1016/j.gpb.2018.03.007. Epub 2019 Jan 9. Genomics Proteomics Bioinformatics. 2018. PMID: 30639122 Free PMC article.

2

Molecular Dynamics Simulations Revealed the Regulation of Ligands to the Interactions between Androgen Receptor and Its Coactivator.

Liu N, Zhou W, Guo Y, Wang J, Fu W, Sun H, Li D, Duan M, Hou T. Liu N, et al. Among authors: fu w. J Chem Inf Model. 2018 Aug 27;58(8):1652-1661. doi: 10.1021/acs.jcim.8b00283. Epub 2018 Jul 20. J Chem Inf Model. 2018. PMID: 29993249 Free PMC article.

3

Reliability of Docking-Based Virtual Screening for GPCR Ligands with Homology Modeled Structures: A Case Study of the Angiotensin II Type I Receptor.

Chen H, Fu W, Wang Z, Wang X, Lei T, Zhu F, Li D, Chang S, Xu L, Hou T. Chen H, et al. Among authors: fu w. ACS Chem Neurosci. 2019 Jan 16;10(1):677-689. doi: 10.1021/acschemneuro.8b00489. Epub 2018 Oct 17. ACS Chem Neurosci. 2019. PMID: 30265513

4

Increased gene copy number of DEFA1/DEFA3 worsens sepsis by inducing endothelial pyroptosis.

Chen Q, Yang Y, Hou J, Shu Q, Yin Y, Fu W, Han F, Hou T, Zeng C, Nemeth E, Linzmeier R, Ganz T, Fang X. Chen Q, et al. Among authors: fu w. Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3161-3170. doi: 10.1073/pnas.1812947116. Epub 2019 Feb 4. Proc Natl Acad Sci U S A. 2019. PMID: 30718392 Free PMC article.

5

Insight into the selective binding mechanism of DNMT1 and DNMT3A inhibitors: a molecular simulation study.

Xie T , Yu J , Fu W , Wang Z , Xu L , Chang S , Wang E , Zhu F , Zeng S , Kang Y , Hou T . Xie T , et al. Among authors: fu w. Phys Chem Chem Phys. 2019 Jun 28;21(24):12931-12947. doi: 10.1039/c9cp02024a. Epub 2019 Jun 5. Phys Chem Chem Phys. 2019. PMID: 31165133

6

Novel androgen receptor antagonist identified by structure-based virtual screening, structural optimization, and biological evaluation.

Tang Q, Fu W, Zhang M, Wang E, Shan L, Chai X, Pang J, Wang X, Xu X, Xu L, Li D, Sheng R, Hou T. Tang Q, et al. Among authors: fu w. Eur J Med Chem. 2020 Apr 15;192:112156. doi: 10.1016/j.ejmech.2020.112156. Epub 2020 Feb 21. Eur J Med Chem. 2020. PMID: 32114360

7

Advances in the computational development of androgen receptor antagonists.

Hu X, Chai X, Wang X, Duan M, Pang J, Fu W, Li D, Hou T. Hu X, et al. Among authors: fu w. Drug Discov Today. 2020 Aug;25(8):1453-1461. doi: 10.1016/j.drudis.2020.04.004. Epub 2020 May 18. Drug Discov Today. 2020. PMID: 32439609 Review.

8

VAD-MM/GBSA: A Variable Atomic Dielectric MM/GBSA Model for Improved Accuracy in Protein-Ligand Binding Free Energy Calculations.

Wang E, Fu W, Jiang D, Sun H, Wang J, Zhang X, Weng G, Liu H, Tao P, Hou T. Wang E, et al. Among authors: fu w. J Chem Inf Model. 2021 Jun 28;61(6):2844-2856. doi: 10.1021/acs.jcim.1c00091. Epub 2021 May 20. J Chem Inf Model. 2021. PMID: 34014672

9

Discovery of a Novel Fusarium Graminearum Mitogen-Activated Protein Kinase (FgGpmk1) Inhibitor for the Treatment of Fusarium Head Blight.

Fu W, Wang E, Ke D, Yang H, Chen L, Shao J, Hu X, Xu L, Liu N, Hou T. Fu W, et al. J Med Chem. 2021 Sep 23;64(18):13841-13852. doi: 10.1021/acs.jmedchem.1c01227. Epub 2021 Sep 14. J Med Chem. 2021. PMID: 34519507

10

Discovery of a Novel Androgen Receptor Antagonist Manifesting Evidence to Disrupt the Dimerization of the Ligand-Binding Domain via Attenuating the Hydrogen-Bonding Network Between the Two Monomers.

Fu W, Zhang M, Liao J, Tang Q, Lei Y, Gong Z, Shan L, Duan M, Chai X, Pang J, Tang C, Wang X, Xu X, Li D, Sheng R, Hou T. Fu W, et al. J Med Chem. 2021 Dec 9;64(23):17221-17238. doi: 10.1021/acs.jmedchem.1c01287. Epub 2021 Nov 22. J Med Chem. 2021. PMID: 34809430

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