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Page 1
B-Raf deficiency impairs tumor initiation and progression in a murine breast cancer model.
Köhler M, Ehrenfeld S, Halbach S, Lauinger M, Burk U, Reischmann N, Cheng S, Spohr C, Uhl FM, Köhler N, Ringwald K, Braun S, Peters C, Zeiser R, Reinheckel T, Brummer T. Köhler M, et al. Among authors: lauinger m. Oncogene. 2019 Feb;38(8):1324-1339. doi: 10.1038/s41388-018-0663-8. Epub 2019 Jan 18. Oncogene. 2019. PMID: 30659267
BRAFΔβ3-αC in-frame deletion mutants differ in their dimerization propensity, HSP90 dependence, and druggability.
Lauinger M, Christen D, Klar RFU, Roubaty C, Heilig CE, Stumpe M, Knox JJ, Radulovich N, Tamblyn L, Xie IY, Horak P, Forschner A, Bitzer M, Wittel UA, Boerries M, Ball CR, Heining C, Glimm H, Fröhlich M, Hübschmann D, Gallinger S, Fritsch R, Fröhling S, O'Kane GM, Dengjel J, Brummer T. Lauinger M, et al. Sci Adv. 2023 Sep;9(35):eade7486. doi: 10.1126/sciadv.ade7486. Epub 2023 Sep 1. Sci Adv. 2023. PMID: 37656784 Free article.
The mTOR pathway controls phosphorylation of BRAF at T401.
Christen D, Lauinger M, Brunner M, Dengjel J, Brummer T. Christen D, et al. Among authors: lauinger m. Cell Commun Signal. 2024 Sep 2;22(1):428. doi: 10.1186/s12964-024-01808-2. Cell Commun Signal. 2024. PMID: 39223665 Free PMC article.