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TRAIL-Expressing Monocyte/Macrophages Are Critical for Reducing Inflammation and Atherosclerosis.
Cartland SP, Genner SW, Martínez GJ, Robertson S, Kockx M, Lin RC, O'Sullivan JF, Koay YC, Manuneedhi Cholan P, Kebede MA, Murphy AJ, Masters S, Bennett MR, Jessup W, Kritharides L, Geczy C, Patel S, Kavurma MM. Cartland SP, et al. Among authors: murphy aj. iScience. 2019 Feb 22;12:41-52. doi: 10.1016/j.isci.2018.12.037. Epub 2019 Jan 4. iScience. 2019. PMID: 30665196 Free PMC article.
Reconstituted high-density lipoprotein increases plasma high-density lipoprotein anti-inflammatory properties and cholesterol efflux capacity in patients with type 2 diabetes.
Patel S, Drew BG, Nakhla S, Duffy SJ, Murphy AJ, Barter PJ, Rye KA, Chin-Dusting J, Hoang A, Sviridov D, Celermajer DS, Kingwell BA. Patel S, et al. Among authors: murphy aj. J Am Coll Cardiol. 2009 Mar 17;53(11):962-71. doi: 10.1016/j.jacc.2008.12.008. J Am Coll Cardiol. 2009. PMID: 19281927 Free article. Clinical Trial.
Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity.
Nagareddy PR, Kraakman M, Masters SL, Stirzaker RA, Gorman DJ, Grant RW, Dragoljevic D, Hong ES, Abdel-Latif A, Smyth SS, Choi SH, Korner J, Bornfeldt KE, Fisher EA, Dixit VD, Tall AR, Goldberg IJ, Murphy AJ. Nagareddy PR, et al. Among authors: murphy aj. Cell Metab. 2014 May 6;19(5):821-35. doi: 10.1016/j.cmet.2014.03.029. Cell Metab. 2014. PMID: 24807222 Free PMC article.
Inhibition of interleukin-1β signalling promotes atherosclerotic lesion remodelling in mice with inflammatory arthritis.
Dragoljevic D, Lee MKS, Louis C, Shihata W, Kraakman MJ, Hansen J, Masters SL, Hanaoka BY, Nagareddy PR, Lancaster GI, Wicks IP, Murphy AJ. Dragoljevic D, et al. Among authors: murphy aj. Clin Transl Immunology. 2020 Nov 9;9(11):e1206. doi: 10.1002/cti2.1206. eCollection 2020. Clin Transl Immunology. 2020. PMID: 33204425 Free PMC article.
IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome.
Murphy AJ, Kraakman MJ, Kammoun HL, Dragoljevic D, Lee MK, Lawlor KE, Wentworth JM, Vasanthakumar A, Gerlic M, Whitehead LW, DiRago L, Cengia L, Lane RM, Metcalf D, Vince JE, Harrison LC, Kallies A, Kile BT, Croker BA, Febbraio MA, Masters SL. Murphy AJ, et al. Cell Metab. 2016 Jan 12;23(1):155-64. doi: 10.1016/j.cmet.2015.09.024. Epub 2015 Oct 22. Cell Metab. 2016. PMID: 26603191 Free article.
Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism.
Lancaster GI, Langley KG, Berglund NA, Kammoun HL, Reibe S, Estevez E, Weir J, Mellett NA, Pernes G, Conway JRW, Lee MKS, Timpson P, Murphy AJ, Masters SL, Gerondakis S, Bartonicek N, Kaczorowski DC, Dinger ME, Meikle PJ, Bond PJ, Febbraio MA. Lancaster GI, et al. Among authors: murphy aj. Cell Metab. 2018 May 1;27(5):1096-1110.e5. doi: 10.1016/j.cmet.2018.03.014. Epub 2018 Apr 19. Cell Metab. 2018. PMID: 29681442 Free article.
Defective cholesterol metabolism in haematopoietic stem cells promotes monocyte-driven atherosclerosis in rheumatoid arthritis.
Dragoljevic D, Kraakman MJ, Nagareddy PR, Ngo D, Shihata W, Kammoun HL, Whillas A, Lee MKS, Al-Sharea A, Pernes G, Flynn MC, Lancaster GI, Febbraio MA, Chin-Dusting J, Hanaoka BY, Wicks IP, Murphy AJ. Dragoljevic D, et al. Among authors: murphy aj. Eur Heart J. 2018 Jun 14;39(23):2158-2167. doi: 10.1093/eurheartj/ehy119. Eur Heart J. 2018. PMID: 29905812 Free PMC article.
Monocytes, Macrophages, and Metabolic Disease in Atherosclerosis.
Flynn MC, Pernes G, Lee MKS, Nagareddy PR, Murphy AJ. Flynn MC, et al. Among authors: murphy aj. Front Pharmacol. 2019 Jun 13;10:666. doi: 10.3389/fphar.2019.00666. eCollection 2019. Front Pharmacol. 2019. PMID: 31249530 Free PMC article. Review.
Specific NLRP3 Inhibition Protects Against Diabetes-Associated Atherosclerosis.
Sharma A, Choi JSY, Stefanovic N, Al-Sharea A, Simpson DS, Mukhamedova N, Jandeleit-Dahm K, Murphy AJ, Sviridov D, Vince JE, Ritchie RH, de Haan JB. Sharma A, et al. Among authors: murphy aj. Diabetes. 2021 Mar;70(3):772-787. doi: 10.2337/db20-0357. Epub 2020 Dec 15. Diabetes. 2021. PMID: 33323396
653 results