Wesolowski G - Search Results

1

Suppression of cathepsin K biomarker in synovial fluid as a free-drug-driven process.

Ma B, Wesolowski G, Luo B, Lifsted T, Wessner K, Adamson G, Glantschnig H, Lubbers LS. Ma B, et al. Among authors: wesolowski g. J Circ Biomark. 2019 Jan 7;8:1849454418821819. doi: 10.1177/1849454418821819. eCollection 2019 Jan-Dec. J Circ Biomark. 2019. PMID: 30671145 Free PMC article.

2

Applicability of in vitro-in vivo translation of cathepsin K inhibition from animal species to human with the use of free-drug hypothesis.

Ma B, Luo B, Euler DH, Cusick TE, Wesolowski G, Glantschnig H, Duong LT, Ou Y, Carroll SS, Lubbers LS. Ma B, et al. Among authors: wesolowski g. Naunyn Schmiedebergs Arch Pharmacol. 2017 Apr;390(4):435-441. doi: 10.1007/s00210-017-1356-5. Epub 2017 Feb 20. Naunyn Schmiedebergs Arch Pharmacol. 2017. PMID: 28220210 Clinical Trial.

3

Determination of in Vivo Enzyme Occupancy Utilizing Inhibitor Dissociation Kinetics.

Murphy DJ, Ou Y, Euler DH, Wessner K, Adamski S, Luo B, Wesolowski GA, Vogel R, Glantschnig H, Lubbers LS, Carroll SS, Lai MT. Murphy DJ, et al. Among authors: wesolowski ga. J Am Chem Soc. 2015 Sep 9;137(35):11230-3. doi: 10.1021/jacs.5b06518. Epub 2015 Aug 27. J Am Chem Soc. 2015. PMID: 26301491

4

Preclinical evaluation of [¹¹ C]L-235 as a radioligand for Positron Emission Tomography cathepsin K imaging in bone.

Bennacef I, Rubins D, Riffel K, Williams M, Posavec DJ, Holahan MA, Purcell ML, Haley HD, Wolf M, Stachel SJ, Lubbers LS, Wesolowski GA, Duong LT, Hamill TG, Evelhoch JL, Hostetler ED. Bennacef I, et al. Among authors: wesolowski ga. J Labelled Comp Radiopharm. 2021 Apr;64(4):159-167. doi: 10.1002/jlcr.3896. Epub 2020 Dec 2. J Labelled Comp Radiopharm. 2021. PMID: 33226657

5

Lead optimization of cathepsin K inhibitors for the treatment of Osteoarthritis.

Ginnetti AT, Paone DV, Nanda KK, Li J, Busuek M, Johnson SA, Lu J, Soisson SM, Robinson R, Fisher J, Webber A, Wesolowski G, Ma B, Duong L, Carroll S, Burgey CS, Stachel SJ. Ginnetti AT, et al. Among authors: wesolowski g. Bioorg Med Chem Lett. 2022 Oct 15;74:128927. doi: 10.1016/j.bmcl.2022.128927. Epub 2022 Aug 6. Bioorg Med Chem Lett. 2022. PMID: 35944849

6

Osteoclast formation, survival and morphology are highly dependent on exogenous cholesterol/lipoproteins.

Luegmayr E, Glantschnig H, Wesolowski GA, Gentile MA, Fisher JE, Rodan GA, Reszka AA. Luegmayr E, et al. Among authors: wesolowski ga. Cell Death Differ. 2004 Jul;11 Suppl 1:S108-18. doi: 10.1038/sj.cdd.4401399. Cell Death Differ. 2004. PMID: 15017384

7

Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis.

Hayami T, Zhuo Y, Wesolowski GA, Pickarski M, Duong LT. Hayami T, et al. Among authors: wesolowski ga. Bone. 2012 Jun;50(6):1250-9. doi: 10.1016/j.bone.2012.03.025. Epub 2012 Mar 30. Bone. 2012. PMID: 22484689

8

Odanacatib reduces bone turnover and increases bone mass in the lumbar spine of skeletally mature ovariectomized rhesus monkeys.

Masarachia PJ, Pennypacker BL, Pickarski M, Scott KR, Wesolowski GA, Smith SY, Samadfam R, Goetzmann JE, Scott BB, Kimmel DB, Duong LT. Masarachia PJ, et al. Among authors: wesolowski ga. J Bone Miner Res. 2012 Mar;27(3):509-23. doi: 10.1002/jbmr.1475. J Bone Miner Res. 2012. PMID: 22113859 Free article.

9

The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model.

Hayami T, Pickarski M, Wesolowski GA, McLane J, Bone A, Destefano J, Rodan GA, Duong LT. Hayami T, et al. Arthritis Rheum. 2004 Apr;50(4):1193-206. doi: 10.1002/art.20124. Arthritis Rheum. 2004. PMID: 15077302 Free article.

10

Efficacy of a cathepsin K inhibitor in a preclinical model for prevention and treatment of breast cancer bone metastasis.

Duong LT, Wesolowski GA, Leung P, Oballa R, Pickarski M. Duong LT, et al. Among authors: wesolowski ga. Mol Cancer Ther. 2014 Dec;13(12):2898-909. doi: 10.1158/1535-7163.MCT-14-0253. Epub 2014 Sep 23. Mol Cancer Ther. 2014. PMID: 25249554

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