Ai J - Search Results

1

Discovery of a potent tyrosine kinase AXL inhibitor bearing the 3-((2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)pyrazine core.

Wang Y, Xing L, Ji Y, Ye J, Dai Y, Gu W, Ai J, Song Z. Wang Y, et al. Among authors: ai j. Bioorg Med Chem Lett. 2019 Mar 15;29(6):836-838. doi: 10.1016/j.bmcl.2019.01.018. Epub 2019 Jan 21. Bioorg Med Chem Lett. 2019. PMID: 30685094

2

Synthesis and c-Met kinase inhibition of 3,5-disubstituted and 3,5,7-trisubstituted quinolines: identification of 3-(4-acetylpiperazin-1-yl)-5-(3-nitrobenzylamino)-7- (trifluoromethyl)quinoline as a novel anticancer agent.

Wang Y, Ai J, Wang Y, Chen Y, Wang L, Liu G, Geng M, Zhang A. Wang Y, et al. Among authors: ai j. J Med Chem. 2011 Apr 14;54(7):2127-42. doi: 10.1021/jm101340q. Epub 2011 Mar 15. J Med Chem. 2011. PMID: 21405128

3

Identification and synthesis of N'-(2-oxoindolin-3-ylidene)hydrazide derivatives against c-Met kinase.

Liang Z, Zhang D, Ai J, Chen L, Wang H, Kong X, Zheng M, Liu H, Luo C, Geng M, Jiang H, Chen K. Liang Z, et al. Among authors: ai j. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3749-54. doi: 10.1016/j.bmcl.2011.04.064. Epub 2011 Apr 22. Bioorg Med Chem Lett. 2011. PMID: 21561768

4

Discovery of novel c-Met kinase inhibitors bearing a thieno[2,3-d]pyrimidine or furo[2,3-d]pyrimidine scaffold.

Zhao A, Gao X, Wang Y, Ai J, Wang Y, Chen Y, Geng M, Zhang A. Zhao A, et al. Among authors: ai j. Bioorg Med Chem. 2011 Jul 1;19(13):3906-18. doi: 10.1016/j.bmc.2011.05.038. Epub 2011 May 24. Bioorg Med Chem. 2011. PMID: 21665484

5

Discovery of 3H-imidazo[4,5-b]pyridines as potent c-Met kinase inhibitors: design, synthesis, and biological evaluation.

Chen D, Wang Y, Ma Y, Xiong B, Ai J, Chen Y, Geng M, Shen J. Chen D, et al. Among authors: ai j. ChemMedChem. 2012 Jun;7(6):1057-70. doi: 10.1002/cmdc.201200120. Epub 2012 May 13. ChemMedChem. 2012. PMID: 22581753

6

Discovery of novel 2-aminopyridine-3-carboxamides as c-Met kinase inhibitors.

Zhang D, Ai J, Liang Z, Li C, Peng X, Ji Y, Jiang H, Geng M, Luo C, Liu H. Zhang D, et al. Among authors: ai j. Bioorg Med Chem. 2012 Sep 1;20(17):5169-80. doi: 10.1016/j.bmc.2012.07.007. Epub 2012 Jul 16. Bioorg Med Chem. 2012. PMID: 22863529

7

Potent HGF/c-Met axis inhibitors from Eucalyptus globulus: the coupling of phloroglucinol and sesquiterpenoid is essential for the activity.

Yang SP, Zhang XW, Ai J, Gan LS, Xu JB, Wang Y, Su ZS, Wang L, Ding J, Geng MY, Yue JM. Yang SP, et al. Among authors: ai j. J Med Chem. 2012 Sep 27;55(18):8183-7. doi: 10.1021/jm3007454. Epub 2012 Sep 7. J Med Chem. 2012. PMID: 22934600

8

Multisubstituted quinoxalines and pyrido[2,3-d]pyrimidines: synthesis and SAR study as tyrosine kinase c-Met inhibitors.

Wu K, Ai J, Liu Q, Chen T, Zhao A, Peng X, Wang Y, Ji Y, Yao Q, Xu Y, Geng M, Zhang A. Wu K, et al. Among authors: ai j. Bioorg Med Chem Lett. 2012 Oct 15;22(20):6368-72. doi: 10.1016/j.bmcl.2012.08.075. Epub 2012 Aug 27. Bioorg Med Chem Lett. 2012. PMID: 22985853

9

Investigation on the 1,6-naphthyridine motif: discovery and SAR study of 1H-imidazo[4,5-h][1,6]naphthyridin-2(3H)-one-based c-Met kinase inhibitors.

Wang Y, Xu ZL, Ai J, Peng X, Lin JP, Ji YC, Geng MY, Long YQ. Wang Y, et al. Among authors: ai j. Org Biomol Chem. 2013 Mar 7;11(9):1545-62. doi: 10.1039/c2ob26710a. Org Biomol Chem. 2013. PMID: 23188156

10

Novel 5-(benzyloxy)pyridin-2(1H)-one derivatives as potent c-Met inhibitors.

Zhang D, Ai J, Liang Z, Zhu W, Peng X, Chen X, Ji Y, Jiang H, Luo C, Geng M, Liu H. Zhang D, et al. Among authors: ai j. Bioorg Med Chem Lett. 2013 Apr 15;23(8):2408-13. doi: 10.1016/j.bmcl.2013.02.037. Epub 2013 Feb 14. Bioorg Med Chem Lett. 2013. PMID: 23474386

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