Dai Y - Search Results

1

Discovery of a potent tyrosine kinase AXL inhibitor bearing the 3-((2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)pyrazine core.

Wang Y, Xing L, Ji Y, Ye J, Dai Y, Gu W, Ai J, Song Z. Wang Y, et al. Among authors: dai y. Bioorg Med Chem Lett. 2019 Mar 15;29(6):836-838. doi: 10.1016/j.bmcl.2019.01.018. Epub 2019 Jan 21. Bioorg Med Chem Lett. 2019. PMID: 30685094

2

Design, synthesis and biological evaluation of novel FGFR inhibitors bearing an indazole scaffold.

Liu J, Peng X, Dai Y, Zhang W, Ren S, Ai J, Geng M, Li Y. Liu J, et al. Among authors: dai y. Org Biomol Chem. 2015 Jul 28;13(28):7643-54. doi: 10.1039/c5ob00778j. Epub 2015 Jun 17. Org Biomol Chem. 2015. PMID: 26080733

3

Design, synthesis and biological evaluation of pyrazolylaminoquinazoline derivatives as highly potent pan-fibroblast growth factor receptor inhibitors.

Fan J, Dai Y, Shao J, Peng X, Wang C, Cao S, Zhao B, Ai J, Geng M, Duan W. Fan J, et al. Among authors: dai y. Bioorg Med Chem Lett. 2016 Jun 1;26(11):2594-9. doi: 10.1016/j.bmcl.2016.04.028. Epub 2016 Apr 12. Bioorg Med Chem Lett. 2016. PMID: 27117427

4

Discovery of Substituted 1H-Pyrazolo[3,4-b]pyridine Derivatives as Potent and Selective FGFR Kinase Inhibitors.

Zhao B, Li Y, Xu P, Dai Y, Luo C, Sun Y, Ai J, Geng M, Duan W. Zhao B, et al. Among authors: dai y. ACS Med Chem Lett. 2016 Apr 20;7(6):629-34. doi: 10.1021/acsmedchemlett.6b00066. eCollection 2016 Jun 9. ACS Med Chem Lett. 2016. PMID: 27326339 Free PMC article.

5

Discovery of 3-(5'-Substituted)-Benzimidazole-5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazoles as Potent Fibroblast Growth Factor Receptor Inhibitors: Design, Synthesis, and Biological Evaluation.

Yan W, Wang X, Dai Y, Zhao B, Yang X, Fan J, Gao Y, Meng F, Wang Y, Luo C, Ai J, Geng M, Duan W. Yan W, et al. Among authors: dai y. J Med Chem. 2016 Jul 28;59(14):6690-708. doi: 10.1021/acs.jmedchem.6b00056. Epub 2016 Jul 6. J Med Chem. 2016. PMID: 27348537

6

Design, Synthesis and Biological Evaluation of 6-(2,6-Dichloro-3,5-dimethoxyphenyl)-4-substituted-1H-indazoles as Potent Fibroblast Growth Factor Receptor Inhibitors.

Zhang Z, Zhao D, Dai Y, Cheng M, Geng M, Shen J, Ma Y, Ai J, Xiong B. Zhang Z, et al. Among authors: dai y. Molecules. 2016 Oct 23;21(10):1407. doi: 10.3390/molecules21101407. Molecules. 2016. PMID: 27782099 Free PMC article.

7

Optimization of 1H-indazol-3-amine derivatives as potent fibroblast growth factor receptor inhibitors.

Cui J, Peng X, Gao D, Dai Y, Ai J, Li Y. Cui J, et al. Among authors: dai y. Bioorg Med Chem Lett. 2017 Aug 15;27(16):3782-3786. doi: 10.1016/j.bmcl.2017.06.068. Epub 2017 Jun 27. Bioorg Med Chem Lett. 2017. PMID: 28687204

8

SOMCL-085, a novel multi-targeted FGFR inhibitor, displays potent anticancer activity in FGFR-addicted human cancer models.

Jiang XF, Dai Y, Peng X, Shen YY, Su Y, Wei MM, Liu WR, Ding ZB, Zhang A, Shi YH, Ai J. Jiang XF, et al. Among authors: dai y. Acta Pharmacol Sin. 2018 Feb;39(2):243-250. doi: 10.1038/aps.2017.96. Epub 2017 Sep 14. Acta Pharmacol Sin. 2018. PMID: 28905937 Free PMC article.

9

Discovery of Potent Irreversible Pan-Fibroblast Growth Factor Receptor (FGFR) Inhibitors.

Wang Y, Li L, Fan J, Dai Y, Jiang A, Geng M, Ai J, Duan W. Wang Y, et al. Among authors: dai y. J Med Chem. 2018 Oct 25;61(20):9085-9104. doi: 10.1021/acs.jmedchem.7b01843. Epub 2018 Mar 16. J Med Chem. 2018. PMID: 29522671

10

Structure-Based Discovery of a Series of 5H-Pyrrolo[2,3-b]pyrazine FGFR Kinase Inhibitors.

Jiang A, Liu Q, Wang R, Wei P, Dai Y, Wang X, Xu Y, Ma Y, Ai J, Shen J, Ding J, Xiong B. Jiang A, et al. Among authors: dai y. Molecules. 2018 Mar 19;23(3):698. doi: 10.3390/molecules23030698. Molecules. 2018. PMID: 29562726 Free PMC article.

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