Antibodies to the extracellular receptor domain restore the hormone-insensitive kinase and conformation of the mutant insulin receptor valine 382.
Lebrun C, Baron V, Kaliman P, Gautier N, Dolais-Kitabgi J, Taylor S, Accili D, Van Obberghen E.
Lebrun C, et al. Among authors: baron v.
J Biol Chem. 1993 May 25;268(15):11272-7.
J Biol Chem. 1993.
PMID: 8388389
Free article.
We have previously demonstrated that in native receptors insulin induces a conformational change in the receptor beta-subunit, which is thought to be necessary for receptor activation (Baron, V., Gautier, N., Komoriya, A., Hainaut, P., Scimeca, J. C., Mervic, M., La …
We have previously demonstrated that in native receptors insulin induces a conformational change in the receptor beta-subunit, which is thou …