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Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation.
Czechowicz A, Palchaudhuri R, Scheck A, Hu Y, Hoggatt J, Saez B, Pang WW, Mansour MK, Tate TA, Chan YY, Walck E, Wernig G, Shizuru JA, Winau F, Scadden DT, Rossi DJ. Czechowicz A, et al. Among authors: tate ta. Nat Commun. 2019 Feb 6;10(1):617. doi: 10.1038/s41467-018-08201-x. Nat Commun. 2019. PMID: 30728354 Free PMC article.
Bleeding the laboratory mouse: Not all methods are equal.
Hoggatt J, Hoggatt AF, Tate TA, Fortman J, Pelus LM. Hoggatt J, et al. Among authors: tate ta. Exp Hematol. 2016 Feb;44(2):132-137.e1. doi: 10.1016/j.exphem.2015.10.008. Epub 2015 Nov 28. Exp Hematol. 2016. PMID: 26644183 Free PMC article.
Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin.
Palchaudhuri R, Saez B, Hoggatt J, Schajnovitz A, Sykes DB, Tate TA, Czechowicz A, Kfoury Y, Ruchika F, Rossi DJ, Verdine GL, Mansour MK, Scadden DT. Palchaudhuri R, et al. Among authors: tate ta. Nat Biotechnol. 2016 Jul;34(7):738-45. doi: 10.1038/nbt.3584. Epub 2016 Jun 6. Nat Biotechnol. 2016. PMID: 27272386 Free PMC article.
Proximity-Based Differential Single-Cell Analysis of the Niche to Identify Stem/Progenitor Cell Regulators.
Silberstein L, Goncalves KA, Kharchenko PV, Turcotte R, Kfoury Y, Mercier F, Baryawno N, Severe N, Bachand J, Spencer JA, Papazian A, Lee D, Chitteti BR, Srour EF, Hoggatt J, Tate T, Lo Celso C, Ono N, Nutt S, Heino J, Sipilä K, Shioda T, Osawa M, Lin CP, Hu GF, Scadden DT. Silberstein L, et al. Cell Stem Cell. 2016 Oct 6;19(4):530-543. doi: 10.1016/j.stem.2016.07.004. Epub 2016 Aug 11. Cell Stem Cell. 2016. PMID: 27524439 Free PMC article.
Rapid Mobilization Reveals a Highly Engraftable Hematopoietic Stem Cell.
Hoggatt J, Singh P, Tate TA, Chou BK, Datari SR, Fukuda S, Liu L, Kharchenko PV, Schajnovitz A, Baryawno N, Mercier FE, Boyer J, Gardner J, Morrow DM, Scadden DT, Pelus LM. Hoggatt J, et al. Among authors: tate ta. Cell. 2018 Jan 11;172(1-2):191-204.e10. doi: 10.1016/j.cell.2017.11.003. Epub 2017 Dec 7. Cell. 2018. PMID: 29224778 Free PMC article.
BCL11A +58/+55 enhancer-editing facilitates HSPC engraftment and HbF induction in rhesus macaques conditioned with a CD45 antibody-drug conjugate.
Demirci S, Zeng J, Palchaudhuri R, Wu C, Abraham DM, Hayal TB, Essawi K, Nguyen MA, Stasula U, Chu R, Leonard A, Porter SN, Khan MBN, Hinojosa G, Uchida N, Hong S, Lazzarotto CR, Neri NR, da Silva LF, Pellin D, Verma A, Lanieri L, Bhat A, Hammond K, Tate T, Maitland SA, Sheikhsaran F, Bonifacino AC, Krouse AE, Linde NS, Engels T, Golomb J, Tsai SQ, Pruett-Miller SM, Scadden DT, Dunbar CE, Wolfe SA, Donahue RE, Olson LM, Bauer DE, Tisdale JF. Demirci S, et al. Cell Stem Cell. 2024 Dec 5:S1934-5909(24)00376-X. doi: 10.1016/j.stem.2024.10.014. Online ahead of print. Cell Stem Cell. 2024. PMID: 39642886
Pparg signaling controls bladder cancer subtype and immune exclusion.
Tate T, Xiang T, Wobker SE, Zhou M, Chen X, Kim H, Batourina E, Lin CS, Kim WY, Lu C, Mckiernan JM, Mendelsohn CL. Tate T, et al. Nat Commun. 2021 Oct 25;12(1):6160. doi: 10.1038/s41467-021-26421-6. Nat Commun. 2021. PMID: 34697317 Free PMC article.
Rosiglitazone and trametinib exhibit potent anti-tumor activity in a mouse model of muscle invasive bladder cancer.
Plumber SA, Tate T, Al-Ahmadie H, Chen X, Choi W, Basar M, Lu C, Viny A, Batourina E, Li J, Gretarsson K, Alija B, Molotkov A, Wiessner G, Lee BHL, McKiernan J, McConkey DJ, Dinney C, Czerniak B, Mendelsohn CL. Plumber SA, et al. Nat Commun. 2024 Aug 2;15(1):6538. doi: 10.1038/s41467-024-50678-2. Nat Commun. 2024. PMID: 39095358 Free PMC article.
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