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Page 1
An ingestible self-orienting system for oral delivery of macromolecules.
Abramson A, Caffarel-Salvador E, Khang M, Dellal D, Silverstein D, Gao Y, Frederiksen MR, Vegge A, Hubálek F, Water JJ, Friderichsen AV, Fels J, Kirk RK, Cleveland C, Collins J, Tamang S, Hayward A, Landh T, Buckley ST, Roxhed N, Rahbek U, Langer R, Traverso G. Abramson A, et al. Among authors: kirk rk. Science. 2019 Feb 8;363(6427):611-615. doi: 10.1126/science.aau2277. Science. 2019. PMID: 30733413 Free PMC article.
Transcellular stomach absorption of a derivatized glucagon-like peptide-1 receptor agonist.
Buckley ST, Bækdal TA, Vegge A, Maarbjerg SJ, Pyke C, Ahnfelt-Rønne J, Madsen KG, Schéele SG, Alanentalo T, Kirk RK, Pedersen BL, Skyggebjerg RB, Benie AJ, Strauss HM, Wahlund PO, Bjerregaard S, Farkas E, Fekete C, Søndergaard FL, Borregaard J, Hartoft-Nielsen ML, Knudsen LB. Buckley ST, et al. Among authors: kirk rk. Sci Transl Med. 2018 Nov 14;10(467):eaar7047. doi: 10.1126/scitranslmed.aar7047. Sci Transl Med. 2018. PMID: 30429357 Clinical Trial.
Oral delivery of systemic monoclonal antibodies, peptides and small molecules using gastric auto-injectors.
Abramson A, Frederiksen MR, Vegge A, Jensen B, Poulsen M, Mouridsen B, Jespersen MO, Kirk RK, Windum J, Hubálek F, Water JJ, Fels J, Gunnarsson SB, Bohr A, Straarup EM, Ley MWH, Lu X, Wainer J, Collins J, Tamang S, Ishida K, Hayward A, Herskind P, Buckley ST, Roxhed N, Langer R, Rahbek U, Traverso G. Abramson A, et al. Among authors: kirk rk. Nat Biotechnol. 2022 Jan;40(1):103-109. doi: 10.1038/s41587-021-01024-0. Epub 2021 Aug 30. Nat Biotechnol. 2022. PMID: 34462588 Free PMC article.
Cephalopod-inspired jetting devices for gastrointestinal drug delivery.
Arrick G, Sticker D, Ghazal A, Lu Y, Duncombe T, Gwynne D, Mouridsen B, Wainer J, Jepsen JPH, Last TS, Schultz D, Hess K, Medina De Alba E, Min S, Poulsen M, Anker C, Karandikar P, Pedersen HD, Collins J, Egecioglu NE, Tamang S, Cleveland C, Ishida K, Uhrenfeldt AH, Kuosmanen J, Pereverzina M, Hayward A, Kirk RK, You S, Dalsgaard CM, Gunnarsson SB, Patsi I, Bohr A, Azzarello A, Frederiksen MR, Herskind P, Li J, Roxhed N, Rahbek UL, Water JJ, Buckley ST, Traverso G. Arrick G, et al. Among authors: kirk rk. Nature. 2024 Dec;636(8042):481-487. doi: 10.1038/s41586-024-08202-5. Epub 2024 Nov 20. Nature. 2024. PMID: 39567682 Free PMC article.
Gastrointestinal Device-Mediated Delivery of mRNA-Lipid Nanoparticles Achieves Distinct Expression and Biodistribution in Mice and Pigs.
Schultz D, Kempen PJ, Primdahl S, Pereverzina M, Uhrenfeldt AH, Alba EMD, Andreasen J, Pedersen HD, Cleveland C, Duncombe T, Ahnfelt-Ro Nne J, Kirk RK, Pfander IB, Sticker D, Water JJ, Buckley ST, Andresen TL, Urquhart AJ. Schultz D, et al. Among authors: kirk rk. ACS Appl Mater Interfaces. 2024 Dec 11;16(49):67192-67202. doi: 10.1021/acsami.4c11819. Epub 2024 Dec 2. ACS Appl Mater Interfaces. 2024. PMID: 39621822
Modulating the Gut Microbiota Improves Glucose Tolerance, Lipoprotein Profile and Atherosclerotic Plaque Development in ApoE-Deficient Mice.
Rune I, Rolin B, Larsen C, Nielsen DS, Kanter JE, Bornfeldt KE, Lykkesfeldt J, Buschard K, Kirk RK, Christoffersen B, Fels JJ, Josefsen K, Kihl P, Hansen AK. Rune I, et al. Among authors: kirk rk. PLoS One. 2016 Jan 22;11(1):e0146439. doi: 10.1371/journal.pone.0146439. eCollection 2016. PLoS One. 2016. PMID: 26799618 Free PMC article.
18F-FDG PET/MR-imaging in a Göttingen Minipig model of atherosclerosis: Correlations with histology and quantitative gene expression.
Ludvigsen TP, Pedersen SF, Vegge A, Ripa RS, Johannesen HH, Hansen AE, Löfgren J, Schumacher-Petersen C, Kirk RK, Pedersen HD, Christoffersen BØ, Ørbæk M, Forman JL, Klausen TL, Olsen LH, Kjaer A. Ludvigsen TP, et al. Among authors: kirk rk. Atherosclerosis. 2019 Jun;285:55-63. doi: 10.1016/j.atherosclerosis.2019.04.209. Epub 2019 Apr 9. Atherosclerosis. 2019. PMID: 31004968
32 results