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Nuclear import of the DSCAM-cytoplasmic domain drives signaling capable of inhibiting synapse formation.
Sachse SM, Lievens S, Ribeiro LF, Dascenco D, Masschaele D, Horré K, Misbaer A, Vanderroost N, De Smet AS, Salta E, Erfurth ML, Kise Y, Nebel S, Van Delm W, Plaisance S, Tavernier J, De Strooper B, De Wit J, Schmucker D. Sachse SM, et al. Among authors: de strooper b, de wit j, de smet as. EMBO J. 2019 Mar 15;38(6):e99669. doi: 10.15252/embj.201899669. Epub 2019 Feb 11. EMBO J. 2019. PMID: 30745319 Free PMC article.
Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin.
Nyabi O, Bentahir M, Horré K, Herreman A, Gottardi-Littell N, Van Broeckhoven C, Merchiers P, Spittaels K, Annaert W, De Strooper B. Nyabi O, et al. Among authors: de strooper b. J Biol Chem. 2003 Oct 31;278(44):43430-6. doi: 10.1074/jbc.M306957200. Epub 2003 Jul 28. J Biol Chem. 2003. PMID: 12885769 Free article.
Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo.
Serneels L, Dejaegere T, Craessaerts K, Horré K, Jorissen E, Tousseyn T, Hébert S, Coolen M, Martens G, Zwijsen A, Annaert W, Hartmann D, De Strooper B. Serneels L, et al. Among authors: de strooper b. Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1719-24. doi: 10.1073/pnas.0408901102. Epub 2005 Jan 21. Proc Natl Acad Sci U S A. 2005. PMID: 15665098 Free PMC article.
410 results