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Modulation of the ATM/autophagy pathway by a G-quadruplex ligand tips the balance between senescence and apoptosis in cancer cells.
Beauvarlet J, Bensadoun P, Darbo E, Labrunie G, Rousseau B, Richard E, Draskovic I, Londono-Vallejo A, Dupuy JW, Nath Das R, Guédin A, Robert G, Orange F, Croce S, Valesco V, Soubeyran P, Ryan KM, Mergny JL, Djavaheri-Mergny M. Beauvarlet J, et al. Nucleic Acids Res. 2019 Apr 8;47(6):2739-2756. doi: 10.1093/nar/gkz095. Nucleic Acids Res. 2019. PMID: 30759257 Free PMC article.
Resistance to the short term antiproliferative activity of the G-quadruplex ligand 12459 is associated with telomerase overexpression and telomere capping alteration.
Gomez D, Aouali N, Londoño-Vallejo A, Lacroix L, Mégnin-Chanet F, Lemarteleur T, Douarre C, Shin-ya K, Mailliet P, Trentesaux C, Morjani H, Mergny JL, Riou JF. Gomez D, et al. J Biol Chem. 2003 Dec 12;278(50):50554-62. doi: 10.1074/jbc.M308440200. Epub 2003 Oct 2. J Biol Chem. 2003. PMID: 14525974 Free article.
82 results