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Page 1
Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase.
AlFadly ED, Elzahhar PA, Tramarin A, Elkazaz S, Shaltout H, Abu-Serie MM, Janockova J, Soukup O, Ghareeb DA, El-Yazbi AF, Rafeh RW, Bakkar NZ, Kobeissy F, Iriepa I, Moraleda I, Saudi MNS, Bartolini M, Belal ASF. AlFadly ED, et al. Among authors: iriepa i. Eur J Med Chem. 2019 Apr 1;167:161-186. doi: 10.1016/j.ejmech.2019.02.012. Epub 2019 Feb 8. Eur J Med Chem. 2019. PMID: 30771604
Synthesis, biological assessment and molecular modeling of new multipotent MAO and cholinesterase inhibitors as potential drugs for the treatment of Alzheimer's disease.
Samadi A, Chioua M, Bolea I, de Los Ríos C, Iriepa I, Moraleda I, Bastida A, Esteban G, Unzeta M, Gálvez E, Marco-Contelles J. Samadi A, et al. Among authors: iriepa i. Eur J Med Chem. 2011 Sep;46(9):4665-8. doi: 10.1016/j.ejmech.2011.05.048. Epub 2011 May 26. Eur J Med Chem. 2011. PMID: 21669479
Chemical and pharmacological studies on enantiomerically pure p-methoxytacripyrines, promising multi-target-directed ligands for the treatment of Alzheimer's disease.
Bartolini M, Pistolozzi M, Andrisano V, Egea J, López MG, Iriepa I, Moraleda I, Gálvez E, Marco-Contelles J, Samadi A. Bartolini M, et al. Among authors: iriepa i. ChemMedChem. 2011 Nov 4;6(11):1990-7. doi: 10.1002/cmdc.201100239. Epub 2011 Aug 24. ChemMedChem. 2011. PMID: 21990269 No abstract available.
Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues.
Martins C, Carreiras MC, León R, de los Ríos C, Bartolini M, Andrisano V, Iriepa I, Moraleda I, Gálvez E, García M, Egea J, Samadi A, Chioua M, Marco-Contelles J. Martins C, et al. Among authors: iriepa i. Eur J Med Chem. 2011 Dec;46(12):6119-30. doi: 10.1016/j.ejmech.2011.09.038. Epub 2011 Sep 29. Eur J Med Chem. 2011. PMID: 22000936
Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine.
Samadi A, de los Ríos C, Bolea I, Chioua M, Iriepa I, Moraleda I, Bartolini M, Andrisano V, Gálvez E, Valderas C, Unzeta M, Marco-Contelles J. Samadi A, et al. Among authors: iriepa i. Eur J Med Chem. 2012 Jun;52:251-62. doi: 10.1016/j.ejmech.2012.03.022. Epub 2012 Mar 30. Eur J Med Chem. 2012. PMID: 22503231
Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amines as potential drugs for the treatment of Alzheimer's disease.
Maalej E, Chabchoub F, Oset-Gasque MJ, Esquivias-Pérez M, González MP, Monjas L, Pérez C, de los Ríos C, Rodríguez-Franco MI, Iriepa I, Moraleda I, Chioua M, Romero A, Marco-Contelles J, Samadi A. Maalej E, et al. Among authors: iriepa i. Eur J Med Chem. 2012 Aug;54:750-63. doi: 10.1016/j.ejmech.2012.06.038. Epub 2012 Jun 28. Eur J Med Chem. 2012. PMID: 22795665
Synthesis, pharmacological assessment, and molecular modeling of acetylcholinesterase/butyrylcholinesterase inhibitors: effect against amyloid-β-induced neurotoxicity.
Silva D, Chioua M, Samadi A, Agostinho P, Garção P, Lajarín-Cuesta R, de Los Ríos C, Iriepa I, Moraleda I, Gonzalez-Lafuente L, Mendes E, Pérez C, Rodríguez-Franco MI, Marco-Contelles J, Carmo Carreiras M. Silva D, et al. Among authors: iriepa i. ACS Chem Neurosci. 2013 Apr 17;4(4):547-65. doi: 10.1021/cn300178k. Epub 2013 Feb 4. ACS Chem Neurosci. 2013. PMID: 23379636 Free PMC article.
Propafenone blocks human cardiac Kir2.x channels by decreasing the negative electrostatic charge in the cytoplasmic pore.
Amorós I, Dolz-Gaitón P, Gómez R, Matamoros M, Barana A, de la Fuente MG, Núñez M, Pérez-Hernández M, Moraleda I, Gálvez E, Iriepa I, Tamargo J, Caballero R, Delpón E. Amorós I, et al. Among authors: iriepa i. Biochem Pharmacol. 2013 Jul 15;86(2):267-78. doi: 10.1016/j.bcp.2013.04.023. Epub 2013 May 3. Biochem Pharmacol. 2013. PMID: 23648307
66 results