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Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase.
AlFadly ED, Elzahhar PA, Tramarin A, Elkazaz S, Shaltout H, Abu-Serie MM, Janockova J, Soukup O, Ghareeb DA, El-Yazbi AF, Rafeh RW, Bakkar NZ, Kobeissy F, Iriepa I, Moraleda I, Saudi MNS, Bartolini M, Belal ASF. AlFadly ED, et al. Among authors: soukup o. Eur J Med Chem. 2019 Apr 1;167:161-186. doi: 10.1016/j.ejmech.2019.02.012. Epub 2019 Feb 8. Eur J Med Chem. 2019. PMID: 30771604
Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity.
Nepovimova E, Korabecny J, Dolezal R, Babkova K, Ondrejicek A, Jun D, Sepsova V, Horova A, Hrabinova M, Soukup O, Bukum N, Jost P, Muckova L, Kassa J, Malinak D, Andrs M, Kuca K. Nepovimova E, et al. Among authors: soukup o. J Med Chem. 2015 Nov 25;58(22):8985-9003. doi: 10.1021/acs.jmedchem.5b01325. Epub 2015 Nov 10. J Med Chem. 2015. PMID: 26503905
Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease.
Lemes LFN, de Andrade Ramos G, de Oliveira AS, da Silva FMR, de Castro Couto G, da Silva Boni M, Guimarães MJR, Souza INO, Bartolini M, Andrisano V, do Nascimento Nogueira PC, Silveira ER, Brand GD, Soukup O, Korábečný J, Romeiro NC, Castro NG, Bolognesi ML, Romeiro LAS. Lemes LFN, et al. Among authors: soukup o. Eur J Med Chem. 2016 Jan 27;108:687-700. doi: 10.1016/j.ejmech.2015.12.024. Epub 2015 Dec 17. Eur J Med Chem. 2016. PMID: 26735910
Synthesis and Biological Evaluation of Benzochromenopyrimidinones as Cholinesterase Inhibitors and Potent Antioxidant, Non-Hepatotoxic Agents for Alzheimer's Disease.
Dgachi Y, Bautista-Aguilera OM, Benchekroun M, Martin H, Bonet A, Knez D, Godyń J, Malawska B, Gobec S, Chioua M, Janockova J, Soukup O, Chabchoub F, Marco-Contelles J, Ismaili L. Dgachi Y, et al. Among authors: soukup o. Molecules. 2016 May 14;21(5):634. doi: 10.3390/molecules21050634. Molecules. 2016. PMID: 27187348 Free PMC article.
Design, synthesis and in vitro evaluation of benzothiazole-based ureas as potential ABAD/17β-HSD10 modulators for Alzheimer's disease treatment.
Hroch L, Benek O, Guest P, Aitken L, Soukup O, Janockova J, Musil K, Dohnal V, Dolezal R, Kuca K, Smith TK, Gunn-Moore F, Musilek K. Hroch L, et al. Among authors: soukup o. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3675-8. doi: 10.1016/j.bmcl.2016.05.087. Epub 2016 May 30. Bioorg Med Chem Lett. 2016. PMID: 27287370
Towards understanding the mechanism of action of antibacterial N-alkyl-3-hydroxypyridinium salts: Biological activities, molecular modeling and QSAR studies.
Dolezal R, Soukup O, Malinak D, Savedra RML, Marek J, Dolezalova M, Pasdiorova M, Salajkova S, Korabecny J, Honegr J, Ramalho TC, Kuca K. Dolezal R, et al. Among authors: soukup o. Eur J Med Chem. 2016 Oct 4;121:699-711. doi: 10.1016/j.ejmech.2016.05.058. Epub 2016 May 30. Eur J Med Chem. 2016. PMID: 27341309
178 results