Yan YH - Search Results

1

Crystallographic and SAR analyses reveal the high requirements needed to selectively and potently inhibit SIRT2 deacetylase and decanoylase.

Yang LL, Xu W, Yan J, Su HL, Yuan C, Li C, Zhang X, Yu ZJ, Yan YH, Yu Y, Chen Q, Wang Z, Li L, Qian S, Li GB. Yang LL, et al. Among authors: yan j, yan yh. Medchemcomm. 2018 Dec 7;10(1):164-168. doi: 10.1039/c8md00462e. eCollection 2019 Jan 1. Medchemcomm. 2018. PMID: 30774863 Free PMC article.

2

X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells.

Yang LL, Wang HL, Zhong L, Yuan C, Liu SY, Yu ZJ, Liu S, Yan YH, Wu C, Wang Y, Wang Z, Yu Y, Chen Q, Li GB. Yang LL, et al. Among authors: yan yh. Eur J Med Chem. 2018 Jul 15;155:806-823. doi: 10.1016/j.ejmech.2018.06.041. Epub 2018 Jun 19. Eur J Med Chem. 2018. PMID: 29957526

3

Structure-Based Development of (1-(3'-Mercaptopropanamido)methyl)boronic Acid Derived Broad-Spectrum, Dual-Action Inhibitors of Metallo- and Serine-β-lactamases.

Wang YL, Liu S, Yu ZJ, Lei Y, Huang MY, Yan YH, Ma Q, Zheng Y, Deng H, Sun Y, Wu C, Yu Y, Chen Q, Wang Z, Wu Y, Li GB. Wang YL, et al. Among authors: yan yh. J Med Chem. 2019 Aug 8;62(15):7160-7184. doi: 10.1021/acs.jmedchem.9b00735. Epub 2019 Jul 17. J Med Chem. 2019. PMID: 31269398

4

MeLAD: an integrated resource for metalloenzyme-ligand associations.

Li G, Su Y, Yan YH, Peng JY, Dai QQ, Ning XL, Zhu CL, Fu C, McDonough MA, Schofield CJ, Huang C, Li GB. Li G, et al. Among authors: yan yh. Bioinformatics. 2020 Feb 1;36(3):904-909. doi: 10.1093/bioinformatics/btz648. Bioinformatics. 2020. PMID: 31504189

5

Principles and current strategies targeting metallo-β-lactamase mediated antibacterial resistance.

Yan YH, Li G, Li GB. Yan YH, et al. Med Res Rev. 2020 Sep;40(5):1558-1592. doi: 10.1002/med.21665. Epub 2020 Feb 25. Med Res Rev. 2020. PMID: 32100311 Review.

6

Sensitive fluorogenic substrates for sirtuin deacylase inhibitor discovery.

Yang LL, Wang HL, Yan YH, Liu S, Yu ZJ, Huang MY, Luo Y, Zheng X, Yu Y, Li GB. Yang LL, et al. Among authors: yan yh. Eur J Med Chem. 2020 Apr 15;192:112201. doi: 10.1016/j.ejmech.2020.112201. Epub 2020 Mar 2. Eur J Med Chem. 2020. PMID: 32163813

7

Therapeutic Effect and Mechanisms of the Novel Monosulfactam 0073.

Sun Y, Liao X, Huang Z, Xie Y, Liu Y, Ma C, Jiang B, Zhang L, Yan Y, Li G, Cheng X, Yin Q, Ding CZ, Shen L, Li J, Chen S, Wei Y, Wang Z, Wei X. Sun Y, et al. Antimicrob Agents Chemother. 2020 Sep 21;64(10):e00529-20. doi: 10.1128/AAC.00529-20. Print 2020 Sep 21. Antimicrob Agents Chemother. 2020. PMID: 32718961 Free PMC article.

8

Discovery of 3-aryl substituted benzoxaboroles as broad-spectrum inhibitors of serine- and metallo-β-lactamases.

Yan YH, Li ZF, Ning XL, Deng J, Yu JL, Luo Y, Wang Z, Li G, Li GB, Xiao YC. Yan YH, et al. Bioorg Med Chem Lett. 2021 Jun 1;41:127956. doi: 10.1016/j.bmcl.2021.127956. Epub 2021 Mar 17. Bioorg Med Chem Lett. 2021. PMID: 33744439

9

Design and enantioselective synthesis of 3-(α-acrylic acid) benzoxaboroles to combat carbapenemase resistance.

Xiao YC, Chen XP, Deng J, Yan YH, Zhu KR, Li G, Yu JL, Brem J, Chen F, Schofield CJ, Li GB. Xiao YC, et al. Among authors: yan yh. Chem Commun (Camb). 2021 Aug 3;57(62):7709-7712. doi: 10.1039/d1cc03026d. Chem Commun (Camb). 2021. PMID: 34259249 Free PMC article.

10

AncPhore: A versatile tool for anchor pharmacophore steered drug discovery with applications in discovery of new inhibitors targeting metallo-β-lactamases and indoleamine/tryptophan 2,3-dioxygenases.

Dai Q, Yan Y, Ning X, Li G, Yu J, Deng J, Yang L, Li GB. Dai Q, et al. Acta Pharm Sin B. 2021 Jul;11(7):1931-1946. doi: 10.1016/j.apsb.2021.01.018. Epub 2021 Jan 26. Acta Pharm Sin B. 2021. PMID: 34386329 Free PMC article.

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