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In vitro modulation of multidrug resistance by pregnane steroids and in vivo inhibition of tumour development by 7α-OBz-11α(R)-OTHP-5β-pregnanedione in K562/R7 and H295R cell xenografts.
Alameh G, Emptoz-Bonneton A, Rolland de Ravel M, Matera EL, Mappus E, Balaguer P, Rocheblave L, Lomberget T, Dumontet C, Le Borgne M, Pugeat M, Grenot C, Cuilleron CY. Alameh G, et al. Among authors: balaguer p. J Enzyme Inhib Med Chem. 2019 Dec;34(1):684-691. doi: 10.1080/14756366.2019.1575825. J Enzyme Inhib Med Chem. 2019. PMID: 30777494 Free PMC article.
The Anti-Cancer Drug Dabrafenib Is a Potent Activator of the Human Pregnane X Receptor.
Creusot N, Gassiot M, Alaterre E, Chiavarina B, Grimaldi M, Boulahtouf A, Toporova L, Gerbal-Chaloin S, Daujat-Chavanieu M, Matheux A, Rahmani R, Gongora C, Evrard A, Pourquier P, Balaguer P. Creusot N, et al. Among authors: balaguer p. Cells. 2020 Jul 8;9(7):1641. doi: 10.3390/cells9071641. Cells. 2020. PMID: 32650447 Free PMC article.
N-1H-benzimidazol-5-ylbenzenesulfonamide derivatives as potent hPXR agonists.
Benod C, Subra G, Nahoum V, Mallavialle A, Guichou JF, Milhau J, Roblés S, Bourguet W, Pascussi JM, Balaguer P, Chavanieu A. Benod C, et al. Among authors: balaguer p. Bioorg Med Chem. 2008 Apr 1;16(7):3537-49. doi: 10.1016/j.bmc.2008.02.020. Epub 2008 Feb 13. Bioorg Med Chem. 2008. PMID: 18304819
A Novel N-Substituted Valine Derivative with Unique Peroxisome Proliferator-Activated Receptor γ Binding Properties and Biological Activities.
Peiretti F, Montanari R, Capelli D, Bonardo B, Colson C, Amri EZ, Grimaldi M, Balaguer P, Ito K, Roeder RG, Pochetti G, Brunel JM. Peiretti F, et al. Among authors: balaguer p. J Med Chem. 2020 Nov 12;63(21):13124-13139. doi: 10.1021/acs.jmedchem.0c01555. Epub 2020 Nov 3. J Med Chem. 2020. PMID: 33142057 Free PMC article.
198 results