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Integrated analysis of population genomics, transcriptomics and virulence provides novel insights into Streptococcus pyogenes pathogenesis.
Kachroo P, Eraso JM, Beres SB, Olsen RJ, Zhu L, Nasser W, Bernard PE, Cantu CC, Saavedra MO, Arredondo MJ, Strope B, Do H, Kumaraswami M, Vuopio J, Gröndahl-Yli-Hannuksela K, Kristinsson KG, Gottfredsson M, Pesonen M, Pensar J, Davenport ER, Clark AG, Corander J, Caugant DA, Gaini S, Magnussen MD, Kubiak SL, Nguyen HAT, Long SW, Porter AR, DeLeo FR, Musser JM. Kachroo P, et al. Among authors: kristinsson kg. Nat Genet. 2019 Mar;51(3):548-559. doi: 10.1038/s41588-018-0343-1. Epub 2019 Feb 18. Nat Genet. 2019. PMID: 30778225 Free PMC article.
Transcriptome Remodeling Contributes to Epidemic Disease Caused by the Human Pathogen Streptococcus pyogenes.
Beres SB, Kachroo P, Nasser W, Olsen RJ, Zhu L, Flores AR, de la Riva I, Paez-Mayorga J, Jimenez FE, Cantu C, Vuopio J, Jalava J, Kristinsson KG, Gottfredsson M, Corander J, Fittipaldi N, Di Luca MC, Petrelli D, Vitali LA, Raiford A, Jenkins L, Musser JM. Beres SB, et al. Among authors: kristinsson kg. mBio. 2016 May 31;7(3):e00403-16. doi: 10.1128/mBio.00403-16. mBio. 2016. PMID: 27247229 Free PMC article.
Evolutionary pathway to increased virulence and epidemic group A Streptococcus disease derived from 3,615 genome sequences.
Nasser W, Beres SB, Olsen RJ, Dean MA, Rice KA, Long SW, Kristinsson KG, Gottfredsson M, Vuopio J, Raisanen K, Caugant DA, Steinbakk M, Low DE, McGeer A, Darenberg J, Henriques-Normark B, Van Beneden CA, Hoffmann S, Musser JM. Nasser W, et al. Among authors: kristinsson kg. Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):E1768-76. doi: 10.1073/pnas.1403138111. Epub 2014 Apr 14. Proc Natl Acad Sci U S A. 2014. PMID: 24733896 Free PMC article.
Reduced In Vitro Susceptibility of Streptococcus pyogenes to β-Lactam Antibiotics Associated with Mutations in the pbp2x Gene Is Geographically Widespread.
Musser JM, Beres SB, Zhu L, Olsen RJ, Vuopio J, Hyyryläinen HL, Gröndahl-Yli-Hannuksela K, Kristinsson KG, Darenberg J, Henriques-Normark B, Hoffmann S, Caugant DA, Smith AJ, Lindsay DSJ, Boragine DM, Palzkill T. Musser JM, et al. Among authors: kristinsson kg. J Clin Microbiol. 2020 Mar 25;58(4):e01993-19. doi: 10.1128/JCM.01993-19. Print 2020 Mar 25. J Clin Microbiol. 2020. PMID: 31996443 Free PMC article.
Population Genomic Molecular Epidemiological Study of Macrolide-Resistant Streptococcus pyogenes in Iceland, 1995 to 2016: Identification of a Large Clonal Population with a pbp2x Mutation Conferring Reduced In Vitro β-Lactam Susceptibility.
Southon SB, Beres SB, Kachroo P, Saavedra MO, Erlendsdóttir H, Haraldsson G, Yerramilli P, Pruitt L, Zhu L, Musser JM, Kristinsson KG. Southon SB, et al. Among authors: kristinsson kg. J Clin Microbiol. 2020 Aug 24;58(9):e00638-20. doi: 10.1128/JCM.00638-20. Print 2020 Aug 24. J Clin Microbiol. 2020. PMID: 32522827 Free PMC article.
A molecular trigger for intercontinental epidemics of group A Streptococcus.
Zhu L, Olsen RJ, Nasser W, Beres SB, Vuopio J, Kristinsson KG, Gottfredsson M, Porter AR, DeLeo FR, Musser JM. Zhu L, et al. Among authors: kristinsson kg. J Clin Invest. 2015 Sep;125(9):3545-59. doi: 10.1172/JCI82478. Epub 2015 Aug 10. J Clin Invest. 2015. PMID: 26258415 Free PMC article.
Antibacterial use in the Faroe Islands, Iceland, and Denmark 1999-2011.
Magnussen MD, Gudnason T, Jensen US, Frimodt-Møller N, Kristinsson KG. Magnussen MD, et al. Among authors: kristinsson kg. Scand J Infect Dis. 2014 Jul;46(7):502-7. doi: 10.3109/00365548.2014.902538. Epub 2014 May 16. Scand J Infect Dis. 2014. PMID: 24832850
192 results