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Unravelling the transcriptional responses of TGF-β: Smad3 and EZH2 constitute a regulatory switch that controls neuroretinal epithelial cell fate specification.
Andrews D, Oliviero G, De Chiara L, Watson A, Rochford E, Wynne K, Kennedy C, Clerkin S, Doyle B, Godson C, Connell P, O'Brien C, Cagney G, Crean J. Andrews D, et al. Among authors: de chiara l. FASEB J. 2019 May;33(5):6667-6681. doi: 10.1096/fj.201800566RR. Epub 2019 Feb 19. FASEB J. 2019. PMID: 30779601
We propose that the interaction between Smad3 and EZH2 targets the core polycomb assembly to defined regions of the genome to regulate transcriptional repression and forms a molecular switch that controls promoter access through epigenetic mechanisms leading to gene silencing.-An …
We propose that the interaction between Smad3 and EZH2 targets the core polycomb assembly to defined regions of the genome to regulate trans …
Polyploid tubular cells initiate a TGF-β1 controlled loop that sustains polyploidization and fibrosis after acute kidney injury.
De Chiara L, Semeraro R, Mazzinghi B, Landini S, Molli A, Antonelli G, Angelotti ML, Melica ME, Maggi L, Conte C, Peired AJ, Cirillo L, Raglianti V, Magi A, Annunziato F, Romagnani P, Lazzeri E. De Chiara L, et al. Am J Physiol Cell Physiol. 2023 Oct 1;325(4):C849-C861. doi: 10.1152/ajpcell.00081.2023. Epub 2023 Aug 29. Am J Physiol Cell Physiol. 2023. PMID: 37642236 Free PMC article.
Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury.
Lazzeri E, Angelotti ML, Peired A, Conte C, Marschner JA, Maggi L, Mazzinghi B, Lombardi D, Melica ME, Nardi S, Ronconi E, Sisti A, Antonelli G, Becherucci F, De Chiara L, Guevara RR, Burger A, Schaefer B, Annunziato F, Anders HJ, Lasagni L, Romagnani P. Lazzeri E, et al. Among authors: de chiara l. Nat Commun. 2018 Apr 9;9(1):1344. doi: 10.1038/s41467-018-03753-4. Nat Commun. 2018. PMID: 29632300 Free PMC article.
Anti-fibrotic treatments: A review of clinical evidence.
Allinovi M, De Chiara L, Angelotti ML, Becherucci F, Romagnani P. Allinovi M, et al. Among authors: de chiara l. Matrix Biol. 2018 Aug;68-69:333-354. doi: 10.1016/j.matbio.2018.02.017. Epub 2018 Apr 11. Matrix Biol. 2018. PMID: 29654884 Review.
Bioengineering strategies for nephrologists: kidney was not built in a day.
Peired AJ, Mazzinghi B, De Chiara L, Guzzi F, Lasagni L, Romagnani P, Lazzeri E. Peired AJ, et al. Among authors: de chiara l. Expert Opin Biol Ther. 2020 May;20(5):467-480. doi: 10.1080/14712598.2020.1709439. Epub 2020 Jan 23. Expert Opin Biol Ther. 2020. PMID: 31971029 Free article. Review.
Acute kidney injury promotes development of papillary renal cell adenoma and carcinoma from renal progenitor cells.
Peired AJ, Antonelli G, Angelotti ML, Allinovi M, Guzzi F, Sisti A, Semeraro R, Conte C, Mazzinghi B, Nardi S, Melica ME, De Chiara L, Lazzeri E, Lasagni L, Lottini T, Landini S, Giglio S, Mari A, Di Maida F, Antonelli A, Porpiglia F, Schiavina R, Ficarra V, Facchiano D, Gacci M, Serni S, Carini M, Netto GJ, Roperto RM, Magi A, Christiansen CF, Rotondi M, Liapis H, Anders HJ, Minervini A, Raspollini MR, Romagnani P. Peired AJ, et al. Among authors: de chiara l. Sci Transl Med. 2020 Mar 25;12(536):eaaw6003. doi: 10.1126/scitranslmed.aaw6003. Sci Transl Med. 2020. PMID: 32213630
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