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Recruitment of RNA Polymerase II to Metabolic Gene Promoters Is Inhibited in the Failing Heart Possibly Through PGC-1α (Peroxisome Proliferator-Activated Receptor-γ Coactivator-1α) Dysregulation.
Bhat S, Chin A, Shirakabe A, Ikeda Y, Ikeda S, Zhai P, Hsu CP, Sayed D, Abdellatif M, Byun J, Schesing K, Tang F, Tian Y, Babu G, Ralda G, Warren JS, Cho J, Sadoshima J, Oka SI. Bhat S, et al. Among authors: oka si. Circ Heart Fail. 2019 Mar;12(3):e005529. doi: 10.1161/CIRCHEARTFAILURE.118.005529. Circ Heart Fail. 2019. PMID: 30798619 Free PMC article.
Hippo Deficiency Leads to Cardiac Dysfunction Accompanied by Cardiomyocyte Dedifferentiation During Pressure Overload.
Ikeda S, Mizushima W, Sciarretta S, Abdellatif M, Zhai P, Mukai R, Fefelova N, Oka SI, Nakamura M, Del Re DP, Farrance I, Park JY, Tian B, Xie LH, Kumar M, Hsu CP, Sadayappan S, Shimokawa H, Lim DS, Sadoshima J. Ikeda S, et al. Among authors: oka si. Circ Res. 2019 Jan 18;124(2):292-305. doi: 10.1161/CIRCRESAHA.118.314048. Circ Res. 2019. PMID: 30582455 Free PMC article.
Both gain and loss of Nampt function promote pressure overload-induced heart failure.
Byun J, Oka SI, Imai N, Huang CY, Ralda G, Zhai P, Ikeda Y, Ikeda S, Sadoshima J. Byun J, et al. Among authors: oka si. Am J Physiol Heart Circ Physiol. 2019 Oct 1;317(4):H711-H725. doi: 10.1152/ajpheart.00222.2019. Epub 2019 Jul 26. Am J Physiol Heart Circ Physiol. 2019. PMID: 31347918 Free PMC article.
Dual peroxisome-proliferator-activated-receptor-α/γ activation inhibits SIRT1-PGC1α axis and causes cardiac dysfunction.
Kalliora C, Kyriazis ID, Oka SI, Lieu MJ, Yue Y, Area-Gomez E, Pol CJ, Tian Y, Mizushima W, Chin A, Scerbo D, Schulze PC, Civelek M, Sadoshima J, Madesh M, Goldberg IJ, Drosatos K. Kalliora C, et al. Among authors: oka si. JCI Insight. 2019 Aug 8;5(17):e129556. doi: 10.1172/jci.insight.129556. JCI Insight. 2019. PMID: 31393858 Free PMC article.
Multiple Levels of PGC-1α Dysregulation in Heart Failure.
Oka SI, Sabry AD, Cawley KM, Warren JS. Oka SI, et al. Front Cardiovasc Med. 2020 Jan 30;7:2. doi: 10.3389/fcvm.2020.00002. eCollection 2020. Front Cardiovasc Med. 2020. PMID: 32083094 Free PMC article. Review.
90 results