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Plasma metabolomic profiling of a ketamine and placebo crossover trial of major depressive disorder and healthy control subjects.
Moaddel R, Shardell M, Khadeer M, Lovett J, Kadriu B, Ravichandran S, Morris PJ, Yuan P, Thomas CJ, Gould TD, Ferrucci L, Zarate CA. Moaddel R, et al. Among authors: lovett j. Psychopharmacology (Berl). 2018 Oct;235(10):3017-3030. doi: 10.1007/s00213-018-4992-7. Epub 2018 Aug 16. Psychopharmacology (Berl). 2018. PMID: 30116859 Free PMC article. Clinical Trial.
Antidepressant-relevant concentrations of the ketamine metabolite (2R,6R)-hydroxynorketamine do not block NMDA receptor function.
Lumsden EW, Troppoli TA, Myers SJ, Zanos P, Aracava Y, Kehr J, Lovett J, Kim S, Wang FH, Schmidt S, Jenne CE, Yuan P, Morris PJ, Thomas CJ, Zarate CA Jr, Moaddel R, Traynelis SF, Pereira EFR, Thompson SM, Albuquerque EX, Gould TD. Lumsden EW, et al. Among authors: lovett j. Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):5160-5169. doi: 10.1073/pnas.1816071116. Epub 2019 Feb 22. Proc Natl Acad Sci U S A. 2019. PMID: 30796190 Free PMC article.
(2R,6R)-hydroxynorketamine exerts mGlu2 receptor-dependent antidepressant actions.
Zanos P, Highland JN, Stewart BW, Georgiou P, Jenne CE, Lovett J, Morris PJ, Thomas CJ, Moaddel R, Zarate CA Jr, Gould TD. Zanos P, et al. Among authors: lovett j. Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6441-6450. doi: 10.1073/pnas.1819540116. Epub 2019 Mar 13. Proc Natl Acad Sci U S A. 2019. PMID: 30867285 Free PMC article.
(R)-Ketamine exerts antidepressant actions partly via conversion to (2R,6R)-hydroxynorketamine, while causing adverse effects at sub-anaesthetic doses.
Zanos P, Highland JN, Liu X, Troppoli TA, Georgiou P, Lovett J, Morris PJ, Stewart BW, Thomas CJ, Thompson SM, Moaddel R, Gould TD. Zanos P, et al. Among authors: lovett j. Br J Pharmacol. 2019 Jul;176(14):2573-2592. doi: 10.1111/bph.14683. Epub 2019 May 13. Br J Pharmacol. 2019. PMID: 30941749 Free PMC article.
Ketamine metabolites, clinical response, and gamma power in a randomized, placebo-controlled, crossover trial for treatment-resistant major depression.
Farmer CA, Gilbert JR, Moaddel R, George J, Adeojo L, Lovett J, Nugent AC, Kadriu B, Yuan P, Gould TD, Park LT, Zarate CA Jr. Farmer CA, et al. Among authors: lovett j. Neuropsychopharmacology. 2020 Jul;45(8):1398-1404. doi: 10.1038/s41386-020-0663-6. Epub 2020 Apr 6. Neuropsychopharmacology. 2020. PMID: 32252062 Free PMC article. Clinical Trial.
Correction: Ketamine metabolites, clinical response, and gamma power in a randomized, placebo-controlled, crossover trial for treatment-resistant major depression.
Farmer CA, Gilbert JR, Moaddel R, George J, Adeojo L, Lovett J, Nugent AC, Kadriu B, Yuan P, Gould TD, Park LT, Zarate CA Jr. Farmer CA, et al. Among authors: lovett j. Neuropsychopharmacology. 2020 Jul;45(8):1405. doi: 10.1038/s41386-020-0699-7. Neuropsychopharmacology. 2020. PMID: 32376872 Free PMC article.
Kynurenines link chronic inflammation to functional decline and physical frailty.
Westbrook R, Chung T, Lovett J, Ward C, Joca H, Yang H, Khadeer M, Tian J, Xue QL, Le A, Ferrucci L, Moaddel R, de Cabo R, Hoke A, Walston J, Abadir PM. Westbrook R, et al. Among authors: lovett j. JCI Insight. 2020 Aug 20;5(16):e136091. doi: 10.1172/jci.insight.136091. JCI Insight. 2020. PMID: 32814718 Free PMC article.
286 results