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The histidine triad nucleotide-binding protein 2 (HINT-2) positively regulates hepatocellular energy metabolism.
Rajasekaran R, Felser A, Nuoffer JM, Dufour JF, St-Pierre MV. Rajasekaran R, et al. Among authors: felser a. FASEB J. 2018 Sep;32(9):5143-5161. doi: 10.1096/fj.201701429R. Epub 2018 Apr 18. FASEB J. 2018. PMID: 29913563
We postulated that the absence of HINT-2 induces a defect in mitochondria bioenergetics. Isolated Hint2(-/-) hepatocytes produced less ATP and generated a lower mitochondrial membrane potential than did Hint2(+/+) hepatocytes. ...The bioenergetics deficit accumulate …
We postulated that the absence of HINT-2 induces a defect in mitochondria bioenergetics. Isolated Hint2(-/-) hepatocytes produced les …
ATG12 deficiency leads to tumor cell oncosis owing to diminished mitochondrial biogenesis and reduced cellular bioenergetics.
Liu H, He Z, Germič N, Ademi H, Frangež Ž, Felser A, Peng S, Riether C, Djonov V, Nuoffer JM, Bovet C, Mlinarič-Raščan I, Zlobec I, Fiedler M, Perren A, Simon HU. Liu H, et al. Among authors: felser a. Cell Death Differ. 2020 Jun;27(6):1965-1980. doi: 10.1038/s41418-019-0476-5. Epub 2019 Dec 16. Cell Death Differ. 2020. PMID: 31844253 Free PMC article.
Triheptanoin - Novel therapeutic approach for the ultra-rare disease mitochondrial malate dehydrogenase deficiency.
Laemmle A, Steck AL, Schaller A, Kurth S, Perret Hoigné E, Felser AD, Slavova N, Salvisberg C, Atencio M, Mochel F, Nuoffer JM, Gautschi M. Laemmle A, et al. Among authors: felser ad. Mol Genet Metab Rep. 2021 Oct 19;29:100814. doi: 10.1016/j.ymgmr.2021.100814. eCollection 2021 Dec. Mol Genet Metab Rep. 2021. PMID: 34712577 Free PMC article.
28 results