Bradley R - Search Results

1

The splicing factor U2AF1 contributes to cancer progression through a noncanonical role in translation regulation.

Palangat M, Anastasakis DG, Fei DL, Lindblad KE, Bradley R, Hourigan CS, Hafner M, Larson DR. Palangat M, et al. Among authors: bradley r. Genes Dev. 2019 May 1;33(9-10):482-497. doi: 10.1101/gad.319590.118. Epub 2019 Mar 6. Genes Dev. 2019. PMID: 30842218 Free PMC article.

2

Genome-wide RNAi screens in human brain tumor isolates reveal a novel viability requirement for PHF5A.

Hubert CG, Bradley RK, Ding Y, Toledo CM, Herman J, Skutt-Kakaria K, Girard EJ, Davison J, Berndt J, Corrin P, Hardcastle J, Basom R, Delrow JJ, Webb T, Pollard SM, Lee J, Olson JM, Paddison PJ. Hubert CG, et al. Among authors: bradley rk. Genes Dev. 2013 May 1;27(9):1032-45. doi: 10.1101/gad.212548.112. Genes Dev. 2013. PMID: 23651857 Free PMC article.

3

U2AF1 mutations alter splice site recognition in hematological malignancies.

Ilagan JO, Ramakrishnan A, Hayes B, Murphy ME, Zebari AS, Bradley P, Bradley RK. Ilagan JO, et al. Genome Res. 2015 Jan;25(1):14-26. doi: 10.1101/gr.181016.114. Epub 2014 Sep 29. Genome Res. 2015. PMID: 25267526 Free PMC article.

4

Spliceosomal gene mutations in myelodysplasia: molecular links to clonal abnormalities of hematopoiesis.

Inoue D, Bradley RK, Abdel-Wahab O. Inoue D, et al. Genes Dev. 2016 May 1;30(9):989-1001. doi: 10.1101/gad.278424.116. Genes Dev. 2016. PMID: 27151974 Free PMC article. Review.

5

RNA splicing factors as oncoproteins and tumour suppressors.

Dvinge H, Kim E, Abdel-Wahab O, Bradley RK. Dvinge H, et al. Nat Rev Cancer. 2016 Jul;16(7):413-30. doi: 10.1038/nrc.2016.51. Epub 2016 Jun 10. Nat Rev Cancer. 2016. PMID: 27282250 Free PMC article. Review.

6

Wild-Type U2AF1 Antagonizes the Splicing Program Characteristic of U2AF1-Mutant Tumors and Is Required for Cell Survival.

Fei DL, Motowski H, Chatrikhi R, Prasad S, Yu J, Gao S, Kielkopf CL, Bradley RK, Varmus H. Fei DL, et al. Among authors: bradley rk. PLoS Genet. 2016 Oct 24;12(10):e1006384. doi: 10.1371/journal.pgen.1006384. eCollection 2016 Oct. PLoS Genet. 2016. PMID: 27776121 Free PMC article.

7

Congenital myotonic dystrophy-an RNA-mediated disease across a developmental continuum.

Jagannathan S, Bradley RK. Jagannathan S, et al. Genes Dev. 2017 Jun 1;31(11):1067-1068. doi: 10.1101/gad.302893.117. Genes Dev. 2017. PMID: 28717044 Free PMC article.

8

Most human introns are recognized via multiple and tissue-specific branchpoints.

Pineda JMB, Bradley RK. Pineda JMB, et al. Genes Dev. 2018 Apr 1;32(7-8):577-591. doi: 10.1101/gad.312058.118. Epub 2018 Apr 17. Genes Dev. 2018. PMID: 29666160 Free PMC article.

9

Impaired hematopoiesis and leukemia development in mice with a conditional knock-in allele of a mutant splicing factor gene U2af1.

Fei DL, Zhen T, Durham B, Ferrarone J, Zhang T, Garrett L, Yoshimi A, Abdel-Wahab O, Bradley RK, Liu P, Varmus H. Fei DL, et al. Proc Natl Acad Sci U S A. 2018 Oct 30;115(44):E10437-E10446. doi: 10.1073/pnas.1812669115. Epub 2018 Oct 15. Proc Natl Acad Sci U S A. 2018. PMID: 30322915 Free PMC article.

10

RNA components of the spliceosome regulate tissue- and cancer-specific alternative splicing.

Dvinge H, Guenthoer J, Porter PL, Bradley RK. Dvinge H, et al. Genome Res. 2019 Oct;29(10):1591-1604. doi: 10.1101/gr.246678.118. Epub 2019 Aug 21. Genome Res. 2019. PMID: 31434678 Free PMC article.

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