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Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs.
Henderson NC, Arnold TD, Katamura Y, Giacomini MM, Rodriguez JD, McCarty JH, Pellicoro A, Raschperger E, Betsholtz C, Ruminski PG, Griggs DW, Prinsen MJ, Maher JJ, Iredale JP, Lacy-Hulbert A, Adams RH, Sheppard D. Henderson NC, et al. Among authors: sheppard d. Nat Med. 2013 Dec;19(12):1617-24. doi: 10.1038/nm.3282. Epub 2013 Nov 10. Nat Med. 2013. PMID: 24216753 Free PMC article.
The αvβ1 integrin plays a critical in vivo role in tissue fibrosis.
Reed NI, Jo H, Chen C, Tsujino K, Arnold TD, DeGrado WF, Sheppard D. Reed NI, et al. Among authors: sheppard d. Sci Transl Med. 2015 May 20;7(288):288ra79. doi: 10.1126/scitranslmed.aaa5094. Sci Transl Med. 2015. PMID: 25995225 Free PMC article.
TGF-β1 Signaling and Tissue Fibrosis.
Kim KK, Sheppard D, Chapman HA. Kim KK, et al. Among authors: sheppard d. Cold Spring Harb Perspect Biol. 2018 Apr 2;10(4):a022293. doi: 10.1101/cshperspect.a022293. Cold Spring Harb Perspect Biol. 2018. PMID: 28432134 Free PMC article. Review.
Loss of Integrin αvβ8 in Murine Hepatocytes Accelerates Liver Regeneration.
Greenhalgh SN, Matchett KP, Taylor RS, Huang K, Li JT, Saeteurn K, Donnelly MC, Simpson EEM, Pollack JL, Atakilit A, Simpson KJ, Maher JJ, Iredale JP, Sheppard D, Henderson NC. Greenhalgh SN, et al. Among authors: sheppard d. Am J Pathol. 2019 Feb;189(2):258-271. doi: 10.1016/j.ajpath.2018.10.007. Epub 2018 Nov 16. Am J Pathol. 2019. PMID: 30448409 Free PMC article.
919 results