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MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo.
Fiedler LR, Chapman K, Xie M, Maifoshie E, Jenkins M, Golforoush PA, Bellahcene M, Noseda M, Faust D, Jarvis A, Newton G, Paiva MA, Harada M, Stuckey DJ, Song W, Habib J, Narasimhan P, Aqil R, Sanmugalingam D, Yan R, Pavanello L, Sano M, Wang SC, Sampson RD, Kanayaganam S, Taffet GE, Michael LH, Entman ML, Tan TH, Harding SE, Low CMR, Tralau-Stewart C, Perrior T, Schneider MD. Fiedler LR, et al. Among authors: jarvis a. Cell Stem Cell. 2019 Apr 4;24(4):579-591.e12. doi: 10.1016/j.stem.2019.01.013. Epub 2019 Mar 7. Cell Stem Cell. 2019. PMID: 30853557 Free PMC article.
MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo.
Fiedler LR, Chapman K, Xie M, Maifoshie E, Jenkins M, Golforoush PA, Bellahcene M, Noseda M, Faust D, Jarvis A, Newton G, Paiva MA, Harada M, Stuckey DJ, Song W, Habib J, Narasimhan P, Aqil R, Sanmugalingam D, Yan R, Pavanello L, Sano M, Wang SC, Sampson RD, Kanayaganam S, Taffet GE, Michael LH, Entman ML, Tan TH, Harding SE, Low CMR, Tralau-Stewart C, Perrior T, Schneider MD. Fiedler LR, et al. Among authors: jarvis a. Cell Stem Cell. 2020 Mar 5;26(3):458. doi: 10.1016/j.stem.2020.01.015. Cell Stem Cell. 2020. PMID: 32142664 Free PMC article. No abstract available.
N-terminal modification of VEGF-A C terminus-derived peptides delineates structural features involved in neuropilin-1 binding and functional activity.
Jia H, Aqil R, Cheng L, Chapman C, Shaikh S, Jarvis A, Chan AW, Hartzoulakis B, Evans IM, Frolov A, Martin J, Frankel P, Djordevic S, Zachary IC, Selwood DL. Jia H, et al. Among authors: jarvis a. Chembiochem. 2014 May 26;15(8):1161-70. doi: 10.1002/cbic.201300658. Epub 2014 Apr 25. Chembiochem. 2014. PMID: 24771685
Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
Jarvis A, Allerston CK, Jia H, Herzog B, Garza-Garcia A, Winfield N, Ellard K, Aqil R, Lynch R, Chapman C, Hartzoulakis B, Nally J, Stewart M, Cheng L, Menon M, Tickner M, Djordjevic S, Driscoll PC, Zachary I, Selwood DL. Jarvis A, et al. J Med Chem. 2010 Mar 11;53(5):2215-26. doi: 10.1021/jm901755g. J Med Chem. 2010. PMID: 20151671 Free PMC article.
Characterization of a bicyclic peptide neuropilin-1 (NP-1) antagonist (EG3287) reveals importance of vascular endothelial growth factor exon 8 for NP-1 binding and role of NP-1 in KDR signaling.
Jia H, Bagherzadeh A, Hartzoulakis B, Jarvis A, Löhr M, Shaikh S, Aqil R, Cheng L, Tickner M, Esposito D, Harris R, Driscoll PC, Selwood DL, Zachary IC. Jia H, et al. Among authors: jarvis a. J Biol Chem. 2006 May 12;281(19):13493-13502. doi: 10.1074/jbc.M512121200. Epub 2006 Mar 2. J Biol Chem. 2006. PMID: 16513643 Free article.
Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGFβ) Production in Regulatory T-Cells.
Powell J, Mota F, Steadman D, Soudy C, Miyauchi JT, Crosby S, Jarvis A, Reisinger T, Winfield N, Evans G, Finniear A, Yelland T, Chou YT, Chan AWE, O'Leary A, Cheng L, Liu D, Fotinou C, Milagre C, Martin JF, Jia H, Frankel P, Djordjevic S, Tsirka SE, Zachary IC, Selwood DL. Powell J, et al. Among authors: jarvis a. J Med Chem. 2018 May 10;61(9):4135-4154. doi: 10.1021/acs.jmedchem.8b00210. Epub 2018 Apr 24. J Med Chem. 2018. PMID: 29648813 Free PMC article.
Essential ingredients for rational drug design.
Jarvis A, Ouvry G. Jarvis A, et al. Bioorg Med Chem Lett. 2019 Oct 15;29(20):126674. doi: 10.1016/j.bmcl.2019.126674. Epub 2019 Sep 6. Bioorg Med Chem Lett. 2019. PMID: 31521476 Review.
281 results